Top 500 Diseases For COMLEX LEVEL 1 Verified Answers!!
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Course
COMLEX
Institution
COMLEX
The COMLEX-USA (Comprehensive Osteopathic Medical Licensing Examination of the United States) is a series of standardized medical board exams designed for osteopathic medical students and physicians. Administered by the National Board of Osteopathic Medical Examiners (NBOME), it evaluates candidate...
TOP 500 DISEASES FOR COMLEX LEVEL 1
VERIFIED ANSWERS!!
Chronic Granulomatous Disease Pathophysiology - Answers ~X-
linked deficiency of NADPH Oxidase leading to phagocyte dysfunction
~Decrease in NADPH oxidase --> lack of superoxide radicals --> lack of
H2O2 production via superoxide dismutase --> decreased HClO from
myeloperoxidase --> Decreased bacterial destruction
~Because the body can't destroy the bacteria, it creates granulomas
around the infection instead
Chronic Granulomatous Disease Diagnosis - Answers
~Dihydrorotamine test: tests the function of NADPH oxidase by watching if
the nitroblue tetrazolium turns blue in the presence of functional NADPH
oxidase
~Positive test = failure to turn blue
Chronic Granulomatous Disease Presentation - Answers
~Susceptible to catalase-positive infections
Staphylococcal Scalded Skin Syndrome Pathophysiology - Answers
~Staph aureus exfoliatin exotoxin A and B target desmoglein, the cadherin
that forms desmosomes to hold cells together
~Destroys the keratinocyte attachments in the stratum granulosum
Staphylococcal Scalded Skin Syndrome Presentation - Answers
~Red rash all over the body
~Palms and soles ARE affected
~Exfoliation of the skin (Nikolsky's sign) - skin sloughs off with gentle
pressure
~Newborns and children/adults with renal insufficiency
~Fever
~Heals COMPLETELY
Toxic Shock Syndrome Pathophysiology - Answers ~S. aureus
superantigen TSST-1 binds MHC-II and T cells at different sites than
normal antigens would --> hyperactive T cell activation --> unproportional
release of IL-2, IL-1b, INFy, and TNFa --> symptoms
~Associated with tampons left in for too long in women and wound
infections in men
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