Pharm One Liners- COMLEX Level 1 With Correct Answers!!
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Course
COMLEX
Institution
COMLEX
The COMLEX-USA (Comprehensive Osteopathic Medical Licensing Examination of the United States) is a series of standardized medical board exams designed for osteopathic medical students and physicians. Administered by the National Board of Osteopathic Medical Examiners (NBOME), it evaluates candidate...
PHARM ONE LINERS- COMLEX LEVEL 1
WITH CORRECT ANSWERS!!
Time required to reduce amount of drug in the body by half during
elimination, constant in first order kinetics (majority of drugs) - Answers
Half life ( T 1/2)
Relates the amount of drug in the body to the plasma concentration -
Answers Volume of distribution (Vd)
Plasma concentration of a drug at a given time - Answers Cp
the ratio of the rate of elimination of a drug to its plasma concentration -
Answers Clearance (CL)
hepatic metabolism of the drug before it reaches the systemic circulation -
Answers First pass effect
The fraction of unchanged drug that reaches systemic circulation after
administration - Answers Bioavailability (F)
when the rate of drug input equals the rate of drug elimination - Answers
steady state
, Q&A
different steps of phase 1 - Answers Oxidation, reduction, hydrolysis
Rifampin, phenobarbital, carbamazepine, phenytoin, St. Johns wort -
Answers Inducers of CYP450
Name three Phase II conjugation reactions - Answers
Glucuronidation, acetylation, glutathione conjugation, sulfation, methylation
Constant fraction of drug eliminated per unit time - Answers First
order kinetics
Constant amount of drug eliminated per unit time - Answers Zero
order kinetics
A higher initial dose given to rapidly achieve effective blood levels -
Answers Loading dose (Cp*(VD/F))
Amount of drug required to keep a desired mean steady-state
concentration in the body - Answers Maintenance dose (Cp*(CL/F))
, Q&A
Ability of a drug to bind to a receptor - Answers affinity
selectivity of a drug for its receptor - Answers speccificity
amount of drug necessary to elicit a biological effect compared with another
drug - Answers potency
ability of drug to produce a maximal effect - Answers efficacy
ability of a drug to produce maximal response after binding to the receptor -
Answers full agonist
ability to produce less than maximal response after binding to receptor -
Answers partial agonist
Ability to bind reversibly to the active site without activating the effector
system - Answers competitive antagonist
Ability to bind irreversibly to the active site or bind to an allosteric site
without activating the effector system - Answers Noncompetitive
antagonist
Mechanism of action utilizes intracellular receptors - Answers
Steroids and hormones
, Q&A
Mechanism of action utilizes transmembrane receptors that have intrinsic
enzymatic activity - Answers Insulin, EGF, TGF beta, PDGF, BNP
Mechanism of action utilizes ligand gated ion channels - Answers
Acetylcholine, nicotine
Dose that produces therapeutic response in 50% of the population -
Answers ED50
Dose that is toxic to 50% of the population - Answers TD50
Dose that is lethal to 50% of a population of animals - Answers
LD50
Window between therapeutic effect and toxic effect - Answers
therapeutic index
Drugs that have a large margin of safety is indicated by - Answers
High therapeutic index
Drugs that have a narrow margin of safety is indicated by - Answers
Low therapeutic index
Antidote for lead poisoning - Answers EDTA, succimer, dimercaprol,
or penicillamine
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