1. refer(s) to specific molecular changes that occur when a drug binds to
mm mm mm mm mm mm mm mm mm mm mm
a particular target site or receptor, while
mm mm mm are the resulting widespread
mm mm mm mm mm mm mm
alterations in function.
mm mm mm
a. Drug action; therapeutic effects
mm mm mm
b. Side effects; drug effects
mm mm mm
c. Therapeutic effects; side effects mm mm mm
d. Drug action; drug effects
mm mm mm
Answer: d mm
Textbook Reference: Pharmacology: The Science of Drug Action
mm mm mm mm mm mm mm
2. After drug administration has occurred, the amount of drug in the blood that is
mm mm mm mm mm mm mm mm mm mm mm mm mm
free to bind at specific target sites is referred to as
mm mm mm mm mm mm mm mm mm mm mm
a. the therapeutic dose.
mm mm
b. first-pass effects. mm
c. bioavailability.
d. ED50.
Answer: c mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
3. The specific molecular changes that occur when a drug binds to a particular
mm mm mm mm mm mm mm mm mm mm mm mm
target site or receptor are referred to as
mm mm mm mm mm mm mm mm
a. drug effects. mm
b. drug action. mm
c. side effects.mm
d. placebo effects. mm
Answer: b mm
Textbook Reference: Pharmacology: The Science of Drug Action
mm mm mm mm mm mm mm
4. Which of the following is not a possible explanation for placebo effects?
mm mm mm mm mm mm mm mm mm mm mm
a. Pavlovian conditioning mm
b. Genetic variation mm
c. Drug competition mm
d. Expectation of outcome mm mm
Answer: c mm
Textbook Reference: Pharmacology: The Science of Drug Action
mm mm mm mm mm mm mm
Page 1 of
mm mm
247
,5. The administration of oxytocin has been proposed as a treatment for autism. mm mm mm mm mm mm mm mm mm mm
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
6. Which factor does not affect the pharmacokinetics of a drug?
mm mm mm mm mm mm mm mm mm
a. Route of administration
mm mm
b. Lipid solubility
mm
c. Depot binding mm
d. Drug action mm
Answer: d mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
7. First-pass metabolism occurs when drugs are taken
mm mm mm mm mm mm
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
8. The area postrema is one area in the brain where the
mm mm is not complete.
mm mm mm mm mm mm mm mm mm mm
a. cerebrospinal fluid mm
b. blood–brain barrier mm
c. choroid plexus mm
d. phospholipid membrane mm
Answer: b mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
9. First-pass metabolism occurs with orally administered drugs because
mm mm mm mm mm mm mm
a. their absorption is slowed by food.
mm mm mm mm mm
b. drugs absorbed into the bloodstream from the stomach go to the liver on the
mm mm mm mm mm mm mm mm mm mm mm mm mm
way to general circulation.
mm mm mm mm
c. drugs must first survive the acidic environment of the stomach.
mm mm mm mm mm mm mm mm mm
d. salivary enzymes in the mouth begin the process of metabolism.
mm mm mm mm mm mm mm mm mm
Answer: b mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
10. Toxic substances in the blood trigger a vomiting response by activating the
mm mm mm mm mm mm mm mm mm mm mm
a. blood–brain barrier. mm
b. choroid plexus. mm
c. area postrema.
mm
d. median eminence. mm
Page 2 of
mm mm
247
, Answer: c mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
11. Drugs administered _ have the most rapid onset of action.
mm mm mm mm mm mm mm mm
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
12. Ionization of a drug depends on the mm of the solution and the
mm mm mm mm mm mm mm mm mm of
the drug.
mm mm
a. pH; pKa mm
b. pKa; pH mm
c. concentration; lipid solubility mm mm
d. pH; concentration
mm
Answer: a mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
13. The absorption of a drug depends on all of the following except
mm mm mm mm mm mm mm mm mm mm mm
a. lipid solubility.
mm
b. ionization.
c. body temperature.
mm
d. the concentration of the drug.
mm mm mm mm
Answer: c mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
14. Drugs that are should be avoided by women of childbearing age.
mm mm mm mm mm mm mm mm mm
a. teratogenic
b. able to cross the placental barrier
mm mm mm mm mm
c. psychoactive
d. highly lipid-soluble mm
Answer: a mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
15. Agents that induce developmental abnormalities in a fetus are known as
mm mm mm mm mm mm mm mm mm mm
a. psychoactive drugs. mm
b. illicit drugs. mm
c. teratogens.
d. placental drugs. mm
Answer: c mm
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
mm mm mm mm mm mm
16. Depot binding is said to occur when drugs
mm mm mm mm mm mm mm
a. bind to their target sites.
mm mm mm mm
Page 3 of
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247
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