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NURS 5315 MSK

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Uploaded on February 1, 2025
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Type Exam (elaborations)
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Course NURS 5315 MSK

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NURS 5315 MSK

Bone Cell Function & Remodeling

1. Question: Which bone cell is primarily responsible for bone
resorption?
o Options: a. Osteoblast b. Osteocyte c. Osteoclast d.
Chondrocyte
o Answer: c. Osteoclast
2. Question: What signaling molecule secreted by osteocytes inhibits
osteoblast activity?
o Options: a. RANK b. Sclerostin c. Cathepsin K d. Osteocalcin
o Answer: b. Sclerostin
3. Question: Which of the following is a biochemical marker of
osteoblast activity?
o Options: a. Tartrate-resistant acid phosphatase (TRAP) b.
Osteocalcin c. Cathepsin K d. Matrix metalloproteinases (MMPs)
o Answer: b. Osteocalcin
4. Question: What is the primary function of osteocytes within the bone
matrix?
o Options: a. Synthesizing osteoid b. Resorbing bone tissue c.
Maintaining bone homeostasis d. Initiating fracture repair
o Answer: c. Maintaining bone homeostasis
5. Question: Which enzyme is secreted by osteoclasts to degrade the
collagen matrix?
o Options: a. Alkaline phosphatase b. Cathepsin K c. Acid
phosphatase d. Osteopontin
o Answer: b. Cathepsin K
6. Statement: Osteoblasts originate from hematopoietic stem cells.
o Answer: False (Osteoblasts originate from mesenchymal stem
cells.)
7. Statement: The RANKL/OPG ratio is critical in regulating osteoclast
activity.
o Answer: True
8. Statement: Sclerostin production by osteocytes is increased in
response to mechanical loading.
o Answer: False (Sclerostin production decreases in response to
mechanical loading.)
9. Statement: Vitamin D deficiency leads to impaired collagen synthesis
in the bone matrix.
o Answer: False (Vitamin D deficiency impairs calcium
absorption, while Vitamin C deficiency affects collagen
synthesis.)
10. Statement: Osteocytes communicate with neighboring cells
through dendritic processes in canaliculi.
o Answer: True
11. Question: What is the role of the RANK/RANKL/OPG system in
bone remodeling?
o Options: a. RANK/RANKL interaction promotes osteoblast
differentiation and activity, leading to bone formation. b.
OPG binds to RANKL, preventing its interaction with RANK,

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