NURS 307 WEEK 1 complete Study
Questions with simplified correct
Answers
CYP 1, CYP 2, CYP 3 - correct answer-drug metabolism
CYP4 - correct answer-Arachidonic acid
CYP5 - correct answer-Thromboxane (blood clotting)
CYP7A, CYP8B, CYP27A - correct answer-Bile acid synthesis
CYP3A - correct answer-- Most important in drug metabolism
- Metabolizes more than 50 drugs
- Most abundantly expressed in human liver
CYP1 - correct answer-- Induced by aromatic hydrocarbons.
- Found in cigarette smoke and charred food.
- High levels linked to colon cancer.
CYP1A2 - correct answer-- Metabolizes CAFFEINE, theophylline.
- Inhibitors: cimetidine, fluvoxamine, ticlopidine, fluroquinolones.
- Inducers: omeprazole, rifampin, TOBACCO.
CYP2C9 - correct answer-- Metabolizes ibuprofen, losartan, WARFAFIN.
- Inhibitors: amiodarone, fluoxetine, METRONIDAZOLE, tmp sulfa, azole antifungals, fluvoastatin,
zafirlukast.
- Inducers: phenobarbital, phenytoin, rifampin.
Drug - correct answer-any chemical that can affect living processes
pharmacology - correct answer-the study of drugs and their interaction with living systems
therapeutics - correct answer-the use of drugs to diagnose, prevent, or treat disease (or pregnancy)
Drug Development Phase 1 - correct answer-Conducted on HEALTHY VOLUNTEERS to evaluate drug
metabolism, pharmacokinetics, and biological effects.
Drug Development Phase 2 - correct answer-Conducted on PATIENTS to assess efficacy and side effects,
dosage range.
Drug Development Phase 3 - correct answer-Testing in PATIENTS to assess efficacy, effectiveness, and
safety; large number of people
Drug Development Phase 4 - correct answer-Post-marketing surveillance watching for drug's long-term
effects; After FDA approval.
Schedule 1 Drug - correct answer-high potential for abuse and NO approved medical use in the U.S.
Schedule 2 Drug - correct answer-Prescriptions for these drugs cannot be refilled; opioids.
Schedule 3 and 4 Drugs - correct answer-Have a potential for abuse; refills must be made within 6
months.
Schedule 5 Drug - correct answer-similar to 3/4 and also drug can be dispensed by pharmacist in limited
amount, must be 18 yrs old, state/local laws don't prohibit dispensing without prescription.
Properties of an ideal drug - correct answer-effective, safe, selective
Effective - correct answer-elicits the response for which it has been administered.
Safe - correct answer-cannot produce harmful effects, even in very high doses over a very long period of
time.
Selective - correct answer-elicits only those responses for which it is given.
Pharmacokinetics - correct answer-movement of drugs within the body
Ways of absorption - correct answer-nose, intestine, skin, lungs
Enterally - correct answer-taking meds orally, vis gastric tube/enteral tube, sublingually, rectal.
Questions with simplified correct
Answers
CYP 1, CYP 2, CYP 3 - correct answer-drug metabolism
CYP4 - correct answer-Arachidonic acid
CYP5 - correct answer-Thromboxane (blood clotting)
CYP7A, CYP8B, CYP27A - correct answer-Bile acid synthesis
CYP3A - correct answer-- Most important in drug metabolism
- Metabolizes more than 50 drugs
- Most abundantly expressed in human liver
CYP1 - correct answer-- Induced by aromatic hydrocarbons.
- Found in cigarette smoke and charred food.
- High levels linked to colon cancer.
CYP1A2 - correct answer-- Metabolizes CAFFEINE, theophylline.
- Inhibitors: cimetidine, fluvoxamine, ticlopidine, fluroquinolones.
- Inducers: omeprazole, rifampin, TOBACCO.
CYP2C9 - correct answer-- Metabolizes ibuprofen, losartan, WARFAFIN.
- Inhibitors: amiodarone, fluoxetine, METRONIDAZOLE, tmp sulfa, azole antifungals, fluvoastatin,
zafirlukast.
- Inducers: phenobarbital, phenytoin, rifampin.
Drug - correct answer-any chemical that can affect living processes
pharmacology - correct answer-the study of drugs and their interaction with living systems
therapeutics - correct answer-the use of drugs to diagnose, prevent, or treat disease (or pregnancy)
Drug Development Phase 1 - correct answer-Conducted on HEALTHY VOLUNTEERS to evaluate drug
metabolism, pharmacokinetics, and biological effects.
Drug Development Phase 2 - correct answer-Conducted on PATIENTS to assess efficacy and side effects,
dosage range.
Drug Development Phase 3 - correct answer-Testing in PATIENTS to assess efficacy, effectiveness, and
safety; large number of people
Drug Development Phase 4 - correct answer-Post-marketing surveillance watching for drug's long-term
effects; After FDA approval.
Schedule 1 Drug - correct answer-high potential for abuse and NO approved medical use in the U.S.
Schedule 2 Drug - correct answer-Prescriptions for these drugs cannot be refilled; opioids.
Schedule 3 and 4 Drugs - correct answer-Have a potential for abuse; refills must be made within 6
months.
Schedule 5 Drug - correct answer-similar to 3/4 and also drug can be dispensed by pharmacist in limited
amount, must be 18 yrs old, state/local laws don't prohibit dispensing without prescription.
Properties of an ideal drug - correct answer-effective, safe, selective
Effective - correct answer-elicits the response for which it has been administered.
Safe - correct answer-cannot produce harmful effects, even in very high doses over a very long period of
time.
Selective - correct answer-elicits only those responses for which it is given.
Pharmacokinetics - correct answer-movement of drugs within the body
Ways of absorption - correct answer-nose, intestine, skin, lungs
Enterally - correct answer-taking meds orally, vis gastric tube/enteral tube, sublingually, rectal.
