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Maryville NURS 615 Pharm (Test 3): Questions With Clear Solutions
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Maryville NURS 615 Pharm (Test 3): Questions With Clear Solutions
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Maryville NURS 615 Pharm (Test 3): Questions WithClear Solutions
What is Colchicine Right Ans - anti-gout medication
How does Colchicine work? Right Ans - Works by inhibiting inflammation,
reducing pain and swelling
How do antigout medications work? Right Ans - by inhibiting the
infiltration and phagocytosis of leukocytes, thus decreasing the breakdown of
uric acid to urate crystals.
Deposition of urate crystals causes Right Ans - pain and inflammation
Common side effects of Colchicine Right Ans - GI problems (diarrhea) use
with caution in elderly
Also can cause blood dyscrasias & abdominal pain
Patient education with Colchicine Right Ans - Can be given with food &
milk to decrease GI issues
Avoid beer, ale, & wine: may cause gout attack
Increase fluid intake: increases excretion of uric acid
Avoid smoked meats & high-protein diets
Low dose of Colchicine Right Ans - Low dose colchicine is 1.2mg followed
by 0.6mg one hour later or 1.8 milligrams total
High dose of Colchicine Right Ans - high dose colchicine is 1.2mg followed
by 0.6mg every four to six hours; or 4.8mg total.
Difference between high dose and low dose Colchicine Right Ans - The
difference between the two is low dose is as effective as high dose with a
lower side effect profile.
Lab values to monitor with Colchicine Right Ans - Check renal function test,
BUN, Creatine
,Patient education with Colchicine Right Ans - Almost always causes some
degree of diarrhea, make sure patients are aware of this side effect
Patient education with Febuxostat (Uloric) Right Ans - Gout may worsen
with therapy initially
Dietary changes to decrease gout attacks and uric acid deposits. Right Ans -
Avoid beer, ale, & wine
Increase fluid intake: increases excretion of uric acid
Avoid smoked meats & high-protein diets
WHO 3 step ladder for pain medication Right Ans -
What is not a first line for pain medication? Right Ans - Narcotics
Recommendations for pain treatment Right Ans - You want to start with
NSAIDs first and then work your way up from there.
Types of Corticosteroid treatment Right Ans - Prednisone, Cortisone,
Dexamethasone
How do Corticosteroids work? Right Ans - Suppress the inflammatory &
immune systems by inhibiting the synthesis of chemical mediators.
What are the chemical mediators that Corticosteroids work on? Right Ans -
Prostaglandins, leukotrienes, & histamines
Corticosteroids and inflammation Right Ans - Decreases inflammation
which decreases swelling, warmth, redness, & pain.
Uses for corticosteroid treatment Right Ans - Addison's disease, hormone
replacement, cancer therapy
SLE, arthritis, IBD, & to suppress graft rejection
Contraindications for corticosteroid treatment Right Ans - Systemic fungal
infections & with live vaccine
Use corticosteroids cautiously with: Right Ans - Pregnancy, kids, HTN,
heart failure, renal impairment, & with infections resistant to treatment
, Patient education with corticosteroids Right Ans - Don't discontinue
abruptly, doses may need increased during stress, symptoms of Cushing's and
GI bleeding
Problem with taking Corticosteroids for greater than 6 months Right Ans -
The main thing you want to worry about is osteoporosis it can also worsen
diabetic control and patients should report any tarry black stools or
abdominal pain.
Other common side effects with Corticosteroids Right Ans - Peptic ulcers,
GI bleeding, edema, hyperglycemia, delayed wound healing, fluid & electrolyte
imbalances
Why is it important to tapper the corticosteroid? Right Ans - Tapering must
be done carefully to avoid both recurrent activity of the underlying disease
process and possible cortisol deficiency resulting from the hypothalamic-
pituitary-adrenal axis or HPA suppression during the period of steroid
therapy
Black box warning Right Ans - Increased risk of serious cardiovascular
thrombotic events, myocardial-infarction and stroke which can be fatal.
What increases risk of black box warning occurring with NSAIDs. Right Ans
- Risk increases with duration of use.
Patients with cardiovascular disease or with risk factors for cardiovascular
disease may be a greater risk.
NSAIDs and GI system Right Ans - Increased risk of serious gastrointestinal
adverse effects including: bleeding, ulceration, and perforation the stomach or
intestines can be fatal.
Can occur at any time during use and without warning symptoms. Elderly
patients are at greater risk for serious GI events.
Ibuprofen and mechanism of action Right Ans - Exact mechanism of action
is unknown.
A non-selective cox-2 inhibitor in that it inhibits two isoforms of psychologic
oxygenase cox-1 and cox-2.
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