DRUGS FINAL EXAM SOLVED #8
Barbituates - correct answer (1903) sedatives
Grouped based on the duration of action
Higher Doses of Barbituates - correct answer induces sleep
Short-acting & rapid onset
Lower Doses of Barbituates - correct answer reduces anxiety
Long-acting & delayed onset
Concerns with Barbituates - correct answer 1.) Overdose deaths (due to respiratory
depressant)
2.) Abuse/dependence (short-acting)
Inhalant Sedatives (Name 3) - correct answer 1.) Gaseous Anesthetics ("laughing gas")
2.) Nitrates (chest pain)
3.) Volatile Solvents (household product - nitrous oxide)
Gaseous Anesthetics - correct answer "Laughing Gas"
Increases blood flow
Treats cyanide poisoning
Nitrates - correct answer still used by dentists
Used in canned whipped cream as propellant
Volatile Solvents - correct answer traced back to 1959
Damages brain, kidneys --> death by suffocation and irritation of respiratory tract
GHB (stands for________) - correct answer Gamma Hydroxybutric Acid
Facts about GHB (Name 6) - correct answer 1.) Naturally occurs in Brain & Body
2.) Similar structure to GABA
3.) Similar behavioral effects to alcohol
4.) Recommended dose = 1-5mg
5.) "date-rape"
Schedule I exception (used to treat narcolepsy and cataplexy)
Alcohol: Behavioral Effects (Name 3) - correct answer 1.) Impacts sexual behavior
2.) Blackouts
3.) Crime & Violence
Stats about Alcohol and Crime & Violence - correct answer homicide = 1/2 involve
alcohol
, Domestic violence = 2/3 "
Suicides = 1/3 "
Sexual assault (reported) = 1/3 "
Papaver Somniferum - correct answer Plant that opium comes from (opium poppy)
Harvested from the pod as a gummy substance (only during 7-10 days of plant's life)
Opium Historical Context - correct answer 6,000 years of medicinal use
First recorded evidence of opium addiction = 1080
Used to be sold over the counter
Opioid - correct answer a drug derived from opium w/ opium-like effects
The primary active ingredient of opium - correct answer Morphine
Morphine was isolated as the primary ingredient in - correct answer 1806
Second active ingredient of opium - correct answer Codeine
When was codeine isolated? - correct answer 1832
Attaching 2 acetyl groups to morphine creates _______. - correct answer Heroine
When was Heroine created - correct answer 1872
Heroine - correct answer - lipophilic: can pass through BBB easier
- originally marketed as a "non-addictive" cough suppressant (1898)
Categories of Opioids (Name 3) - correct answer 1.) Natural (derived from plant)
2.) Semi-synthetic (partially natural, partially synthetic)
3.) Synthetic (lab produced)
Examples of Natural Opioids (Name 2) - correct answer Morphine
Codeine
Example of Semi-Synthetic Opioids (Name 1) - correct answer Heroin
Examples of Synthetic Opioids (Name 2) - correct answer Fentanyl
Methadone
Receptors Specific to Opioids (Name 3) - correct answer 1.) Mu (pain perception)
2.) Kappa (pain perception)
3.) Delta (chronic pain)
Narcan (Naloxone) - correct answer opioid antagonist (blocks receptor)