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NAGELHOUT-PHARM 2-EXAM 1 QUESTIONS AND ANSWERS (GRADED A+) $16.99
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NAGELHOUT-PHARM 2-EXAM 1 QUESTIONS AND ANSWERS (GRADED A+)

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NAGELHOUT-PHARM 2-EXAM 1 QUESTIONS AND ANSWERS (GRADED A+)NAGELHOUT-PHARM 2-EXAM 1 QUESTIONS AND ANSWERS (GRADED A+) Ultra short acting neuromuscular blocker (Length of duration) - ANSWER-Succinylcholine (5 - 15 minutes) Depolarizing NMB - ANSWER-Succinylcholine Intermediate Acting Nondepo...

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  • March 12, 2025
  • 13
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NAGELHOUT-PHARM 2
  • NAGELHOUT-PHARM 2
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NAGELHOUT-PHARM 2-EXAM 1
QUESTIONS AND ANSWERS (GRADED
A+)
Ultra short acting neuromuscular blocker
(Length of duration) - ANSWER-Succinylcholine
(5 - 15 minutes)

Depolarizing NMB - ANSWER-Succinylcholine

Intermediate Acting Nondepolarizing NMBs (4)
(Length of duration) - ANSWER-Atracurium
Cisatracurium
Vecuronium
Rocuromium
(30-60 minutes)

Long Acting Nondepolarizing NMB
(Length of duration) - ANSWER-Pancuronium
60-90 minutes

Short Acting Nondepolarizing NMBs
(Length of duration) - ANSWER-None
(20-30 minutes)

NMB Reversal Agents (3) - ANSWER-Neostigmine
Edrophonium
Sugammadex (not approved by FDA)

NMBs work at ____ receptors - ANSWER-Nicotinic Cholinergic (sub-m)

Neurotransmitter of the NM junction - ANSWER-acetylcholine

Breaks down acetylcholine at the NM synapse/junction - ANSWER-acetylcholinesterase

Non-depolarizing agents are: agonists or antagonists - ANSWER-Antagonist

Depolarizing agents act as: agonist or antagonist?? - ANSWER-Agonist then antagonist

Onset time definition - ANSWER-time from drug administration to maximum effect

, Clinical duration definition - ANSWER-time from drug administration to 25% recovery of
twitch response

Total duration of action definition - ANSWER-time from drug administration to 90%
recovery of twitch response (point at which pt is recovered)

Recovery index definition - ANSWER-time from 25% to 75% recovery of twitch
response (how fast?)

Train of Four Index - ANSWER-4th twitch of TOF/1st twitch of TOF

Muscle stimulated by ulnar nerve in TOF - ANSWER-Adductor pollicis

Best nerve/muscle to measure onset of NMB - ANSWER-Facial Nerve
Orbicularis Oculi (Corrugator supercilii = best)
(reflects diaphragm blockade)

Best nerve/muscle to measure emersion from NMB - ANSWER-Ulnar Nerve
Adductor Pollicis

Single Twitch Test - ANSWER-1.0 Hz
Single stimulus
Compares pre (baseline) and post NMB hand twitch

Train of Four Test - ANSWER-4 - 2 Hz twitches
Compares 4th twitch to 1st twitch (fade)
Reflects 70-100% blockade

Double Burst Simulation (DBS) Test - ANSWER-2 - 50 Hz twitches
0.75 seconds apart
Compares 2 twitches to monitor for fade

Tetanus Test - ANSWER-100 Hz twitch for 5 seconds
Painful

Posttetanic Count Test - ANSWER-50 Hz stimulus for 5 sec → 3 sec pause → 1 Hz
single twitch every second
Only used when patient is 100% paralyzed
More post-tetanic twitches = closer to recovery

Sequence of muscle paralysis - ANSWER-1. Eyelids (Protective muscles of pharynx)
2. Extremities
3. Chest (neck downward)
4. Abdominal muscles
5. Diaphragm

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