verified ANSWERS
What is Acetazolamide used for? - -----Answers----It can
treat glaucoma, epilepsy, mountain sickness, and fluid
retention (edema).
What is the 1st line agent for anxiety? - -----Answers-----
SSRI and SNRI
Why some clinicians overlap SNRI or SSRI with
beznodiazepines? - -----Answers----- Clinicians may overlap
SSRI or SNRI with a benzodiazepin for 2-4 weeks to help
alleviate the initial stimulatory effect and regulate sleep.
Noticeable improvement may be see after .... or more weeks of
treatment for anxiety. - -----Answers----4 weeks
What is buspar used for? - -----Answers----- Binds to
serotonin type 1A receptors (agonist). Serotonergic activity
contributes to anxiolytic actons and anti-depressant actions.
- Buspar is a second line option for GAD (only FDA approved
indication). It is an alternative for patients who do not respond
to antidepressants, are at risk for BZD abuse or added as
adjunctive therapy. It has delayed onset of 2-4 weeks, shorter
than SSRIs but longer than BZDs.
What is Hydroxyzine used for? - -----Answers----- Vistrail
,- an FDA approved or anxiety and is considered second-line.
- It is occasionally used for short-term anxiety in lieu of BZDs
that have the potential for abuse.
- This is a sedating antihistamine and works by sedating the
patient, rather than treating any underlying cause. IT should
not be used long-term.
- It is also used for pruritus
what would you give a patient that comes to ur community
pharmacy (Walgreens) and has 1. anxiety 2. neuropathic pain.
Looking for one medication that treat both? - -----Answers---
-Lyrica
- * is not fda * approved for anxiety but is useful if a patient
has anxiety with neuropathic pain.
- Pregabalin has immediate anxiolytic effect similar to BZDs.
- Schedule C-V
What is the rule of Propronalol in anxiety? - -----Answers----
- It is used to reduce symptoms of stage fright or performance
anxity.
- It is dosed at 10-40 mg 1 hour prior to an event such as a
public speech.
List some natural products used for anxiety - -----Answers--
--- Valerian
> some products maybe contaminated with liver toxins
- Lemon balm
,- Glutamine
- Passion flower
- hops
- Chamomile tea
- Theanine and skullcap
- Kava
> Hepatotoxic
When do you want to use Benzodiazepines? - -----Answers--
--- They provide fast relief 30 mins to 2 hours
- Appropriate in short term situations where anxiety is acute
and can cause extreme stress, prevent proper sleep, and
disrupt life.
> Ex. Death of loved one, earth quake, motor vehicle accident,
etc.
- Should use it for less than 1-2 weeks and then discontinued.
- Should not be used in long term
- Do not use in elderly
> confusion, dizziness, and fall
What is the MOA of benzodiazepines? - -----Answers-----
Potentiation of GABA
- They are differentiated by onset of action and duration of
activity
, Which benzodiazepines comes as ODT? - -----Answers-----
Alprazolam
- Clonazepam
Which benzodiazepin comes as solution? - -----Answers-----
Alprazolam
- Lorazepam
- Diazepam
Benzodiazepines - Safety / side effect / Monitoring - -----
Answers----- CI
> Myasthenia gravis , severe respiratory insufficiency, severe
hepatic insufficiency, sleep apnea syndrome, acute narrow-
angel glaucoma, not for use in infants < 6 months of age (oral)
- Warning
- Anterograde amnesia (after drug is taken some events may
not be stored as memories)
- CNS depression
- Extravasation with IV administration
- Potential for abuse
- risks in elderly
- development of tolerance, withdrawal following abrupt
discontinuation or large decrease in dose; taper off slowly
- potential for abuse
- physiological dependence and tolerance develop with chronic
use