ALREADY GRADED A+
what is the standard dosing range of escitalopram? 10-20mg/day
what is the starting dose of escitalopram? 10mg/day
what is the CYP 450 of escitalopram? minimal; minimal drug interactions
What is fluoxetine used for? depression, PMDD, OCD
GAD/panic disorder (possibly)
is fluoxetine activating or sedating? activating; good for patient who has a hard time getting
out of bed
what is the dosage range of fluoxetine? 20-80mg/day
what is the starting dose of fluoxetine? 20mg in the AM
how long is the half life of fluoxetine? long- approx 10-14 days
what is the CYP 450 of fluoxetine? inhibits 2d6 and 3a4
when can an MAOI be started after fluoxetine use? 5 weeks
,who would you consider for fluoxetine use? atypical depression (hypersomnia, hyperphagia,
low energy, mood reactivity)
What is Paroxetine used for? SSRI
depression, ocd, panic, GAD
what are the most common side effects of paroxetine? constipation, dry mouth, sedation
weight gain, sedation
what is the dosage range of paroxetine? 20-50mg/day
what is the starting dose of paroxetine? 20mg x few weeks
titrate by 10mg if needed
what patients should have a lower dose of paroxetine? renal and hepatic
how does paroxetine affect CYP 450? inhibits 2d6 (potent)
who is best canidate for paroxetine? anxious depression patients
what can happen when paroxetine is stopped? withdrawal effect/discontinuation syndrome
What is sertraline used for? SSRI, depression
, Panic disorder
OCD
Social anxiety disorder
PTSD
what is the dosage range for sertraline? 50-200mg/day
what is the starting dose of sertraline? 50mg/day
how does sertraline affect CYP 450? minimally (2d6, 3A4)
who might sertraline be good for? atypical depression
What is lamotrigine used for? MOOD STABILIZER
-Efficacy in bipolar , little efficacy for acute mania or prevention of mania (better for bipolar
depression)
-MOA: sodium channels that modulate glutamate and aspartate
-SE: MC are dizziness, sedation, HA, and ataxia, most serious is Stevens-Johnson Syndrome in
10% (most likely in first 4-6 weeks, go low and slow to avoid)
-Valproate increases lamotrigine levels and lamotrigene decreases valproate levels
what is the dosage range for lamotrigine? 100-200mg/day