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Biochemistry Glycolysis Lecture Notes
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Glycolysisstepwisedegradationglucose
Ancient process used by almostall organisms
Anaerobicprocess before02existed
in cytosol
Aerobicorganisms
Endproduct Uted aerobicmetabolicprocesses
glycolysis
anaerobic
Quicketource in absence02
Essential Features
1 glucose s 2pymrates
OC 2 30
Halo enzymecatalyzed steps brain
Only tourcemetabolicEnergy kidney
contractingskeletalmuscle
erythrocytes
opermoeus
pyruvate _versatile metabolite dependanton availability02
02 AcetylCOAT CO2 aerobicconditions
Oz Lactate Mammals Anaerobic
Os s ethanol CO2 fermentation conditions
TWOphases
re1 s
phare20
I Glucote s 2GAP 2GAP s 2 pyruvate
2 importantphosphorylationAcpf Ant LATP produced
1AM 1 1 permolecule
rxn5 run 10 2 ATPproduced
UN Energy run6 2 reducedcoenzymes
MADH
NO Energyproduced
,snapshot
quote
Rxn phoophorylation
HekokinatelGlucokinate
ftp.rimingrxn
ATPrequired
Gbp
Rxn isomerization
phospnoglucoisomerate Mg
phosphorylation
RXn phoophotructokinate Mg
2nd priming ran
ATPrequired
cleavage WHOO
compoundintohalf
RXh Fructose bisphosphate Aldolate
product _2 30 intermediates
Rxn isomerization
Triotophosphateisomerate
Oxidation
Rxn Glyceraldehyde 3 phosphate Dehydrogenate
prods _night intermediate
phoophoglycerate kinase Mg
RXn regeneratesATP that was used in phatel
phosphoryl transferrin
RXn phosphoglycerate mutate
Rxn Dehydration
Enolate Mg
prod PEP
RM pyruvateKinane Mg
Prod pyruvate
ATP
, 60 sugar
pharelcheocore
6 CH2OH
H to O DUDULOOE
Ignore s2GAp 4 OH HOH
H 1
UH 3 2
H OH
Ipi
n.ph
Hexokinaoelalueokinaoe
u
Glucose 6 phosphate Gbp
phoophoglucoisomerate
Fructote b phorphate Flop
ATP
phoophotructokinate
L
U
Fructose 1,6 bisphosphate FBP
Fructose
bisphosphate S
Aldolase
Dihydroxyacetone Glyceraldehyde b phosphate
phosphate AAP
DHAP Gbp
Tn'Oiffffffamhmategg
Glyceraldehyde 3 phosphate
GAP
GBP
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