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The composition and volume of body fluid is regulated by ______
The composition and volume of body fluid is regulated by ______
Kidney
Composition of Body Fluids

Electrolytes
Composition of Body Fluids

Electrolytes
- have electrical charge when dissolved in water (ions)
- DOES: dissociate into ions in water
- ions conduct electrical current
- GREATER osmotic power
- greater ability to cause fluid movement
Fluid Movement Among Compartments

list important and general information
Fluid Movement Among Compartments

list important and general information
- change in solute concentration of any compartment leads to net water flow
- More ECF solute concetration= water leaves cells
- Less ECF solute concentration= water enters cells
Regulation of Water Output

list important and general information
Regulation of Water Output

list important and general information
Water loss
- uncontrollable water loss due to metabolism (urine & feces)
-2.5 L in= 2.5 L out
Central Role of Sodium in Fluid and Electrolyte Balance

List general and important information on Sodium
Central Role of Sodium in Fluid and Electrolyte Balance

List general and important information on S...
- Sodium is most abundant cation in ECF
- REMEMBER: water follows Sodium
- Only cation exerting significant osmotic pressure
- Controls ECF volume and water distribution because water follows sodium
- Change in Na+ level affects plasma volume, blood pressure, ECF & IF volumes
Central Role of Sodium in Fluid and Electrolyte Balance

Regulation of Sodium Balance in depth information
Central Role of Sodium in Fluid and Electrolyte Balance

Regulation of Sodium Balance in depth infor...
- Renin - angiotensin - aldosterone mechanism is main trigger for aldosterone release

- Granular cells of JGC secrete renin is response to:
- Decrease Na+ concentrationn
- Decreased stretch of granular cells, due to decreased blood pressure
- Causes adrenal glands to release aldosterone
EFFECT= blood pressure goes up blood volume goes up
lists the 3 main buffering systems
lists the 3 main buffering systems
- Bicarbonate buffer system
- Phosphate buffer system
- Protein buffer system
Renal pH Regulation

lists general and important information
Renal pH Regulation

lists general and important information
- the ultimate long-term regulation of acid-base balance
- besides bicarbonate buffering--> main one
- Kidneys eliminate other acids produced by cellular metabolism (phosphoric, uric, and lactic acids and ketones) to prevent metabolic acidosis