Carmustine bcnu - Study guides, Class notes & Summaries

BMTCN Review Chapter 4 - Transplant Preparative Regimens, Cellular Infusion, Acute Complications, and EngraftmentTRANSPLANT PREP REGIMENS - correct answer Treatment leading up to transplant Acronyms: Ara-C BCNU BU Cy DLT SCT TBI - correct answer Cytarabine Carmustine Busulfan Cyclophosphamide Dose limiting toxicity DStem cell transplant Total body irradiation Induction chemotherapy - correct answer The first treatment given for a disease. It is often part of a standard set of ...

What do alkylating agents do? correct answer: Active throughout cell cycle. Causes breaks in DNA helix, preventing replication and transcription of RNA. What are the alkylating agent drugs? correct answer: Bendamustine (Treanda) Busulfan (Myleron) Carboplatin (Paraplatin) Carmustine (BCNU) Chlorambucil (Leukeran) Cisplatin (Platinol, CDDP) Cyclophosphamide (Cytoxan, CTX) Dacarbazine (DTIC) Ifosfamide (Iflex) Mechlorethamine (Nitrogen Mustard) Melphalan (Alkeran) Oxaliplatin (Elo...

BMTCN ATG - correct answer anti t-cell globulin prevents GVHD, graft failure premeds: Tylenol, corticosteroids, Benadryl SE: hypotension, chills, rigors, fevers, pulmonary edema serum sickness - correct answer ATG myalgias, arthralgias, fever, rash, hand/facial edema give steroids BCNU (carmustine) - correct answer alkylating agent pre/post hydration SE: n/v, nephrotoxicity (elevated creat), pulmonary toxicity (pulmonary fibrosis, acute lung injury) infusion rx: feeling drunk, hy...

BMTCN Chapter 4 BCNU - correct answer Carmustine Causes DNA Cross links and strand breaks Inhibits DNA repair Crosses blood/brain barrier Need pre/post hydration BCNU Side Effects - correct answer N/V Infusion reactions nephrotoxicity (increased Crea & BUN) pulmonary - cough, dyspnea, tachypnea acute lung injury - 10-30 days post infusion (tx w/ steroids; can be fatal) Busulfan - correct answer *Alkylating agent*-->cross-links DNA-->damages DNA Crosses blood brain barrier...

BMTCN Medication Question and answers correctly solved 2023/2024 ATG - correct answer Immune Suppressant. not recommended for reduced intensity regimens s/s pulm edema, hepatic dysfunction. Skin rash,joint pains(serum Sickness-TREATED WITH STEROIDS) Used before Allo for immunosuppression and later to treat GVHD. BCNU(carmustine) - correct answer nephro toxic pulm toxic-cough, dyspnea, Busulfan - correct an

BMTCNATG - correct answer anti t-cell globulin prevents GVHD, graft failure premeds: Tylenol, corticosteroids, Benadryl SE: hypotension, chills, rigors, fevers, pulmonary edema serum sickness - correct answer ATG myalgias, arthralgias, fever, rash, hand/facial edema give steroids BCNU (carmustine) - correct answer alkylating agent pre/post hydration SE: n/v, nephrotoxicity (elevated creat), pulmonary toxicity (pulmonary fibrosis, acute lung injury) infusion rx: feeling drunk, hypo...

BMTCN ch.04preparative regimens - correct answer aka conditioning regiment part of HSCT when tx malignant diseases goal: eradicate residual disease and/or provide immunosuppression to prevent graft rejection prepare receipients bone marrow to accept new donor cells examples of chemo - correct answer cyclophosphamide busulfan etoposide cytarabine carmustine melphalan myeloablative regimens - correct answer lethal doses of chemo (usually includes alkylating agents) with or without TB...

BMTCN ch.04 preparative regimens - correct answer aka conditioning regiment part of HSCT when tx malignant diseases goal: eradicate residual disease and/or provide immunosuppression to prevent graft rejection prepare receipients bone marrow to accept new donor cells examples of chemo - correct answer cyclophosphamide busulfan etoposide cytarabine carmustine melphalan myeloablative regimens - correct answer lethal doses of chemo (usually includes alkylating agents) with or without ...

BMTCN MedicationATG - correct answer Immune Suppressant. not recommended for reduced intensity regimens s/s pulm edema, hepatic dysfunction. Skin rash,joint pains(serum Sickness-TREATED WITH STEROIDS) Used before Allo for immunosuppression and later to treat GVHD. BCNU(carmustine) - correct answer nephro toxic pulm toxic-cough, dyspnea, Busulfan - correct answer neurotoxic SEIZURE-use levetiracetam hepatitis, VOD, rash, hairloss may be permanent pulmonary fibrosis premenopausal...

BMTCN Chapter 4BCNU - correct answer Carmustine Causes DNA Cross links and strand breaks Inhibits DNA repair Crosses blood/brain barrier Need pre/post hydration BCNU Side Effects - correct answer N/V Infusion reactions nephrotoxicity (increased Crea & BUN) pulmonary - cough, dyspnea, tachypnea acute lung injury - 10-30 days post infusion (tx w/ steroids; can be fatal) Busulfan - correct answer *Alkylating agent*-->cross-links DNA-->damages DNA Crosses blood brain barrier (...