Nst 160 midterm 1 - Study guides, Class notes & Summaries

NST 160 Midterm 2 Exam Questions and Answers Inflammation causing insulin resistance pathway - ANSWER High fat diets and obesity cause adipose to release TNF-alpha and TNF-alpha binds to receptor which inactivates IRS by phosphorylating. TNF-alpha also activates JNK and IKK-B which both inhibit IRS and activate NF-KB which is a transcription factor that down regulates insulin signaling components. Also, cytokines and lipids activate serine kinases that phosphorylate IRS-1 and IRS-2...