P gp substrate - Study guides, Class notes & Summaries

NAPLEX 2022 with complete solutions Common CYP Inhibitors G: Grapefruit Pacman: Protease Inhibitors (ritonavir) Azole antifungals: Fluconazole, ketoconazole, ect. Cyclosporine Macrolides: Clarithromycin, erythromycin, not azith Amiodarone Non-DHP CCBs: Dilt and verap CYP Inducers Phenytoin Smoking Phenobarbital Oxacarbazepine Rifampin Carbamazepine St. John's wort P-gp Substrate Antiocoags: apixaban, edoxaban CVD Drugs: digoxin, dilt, carvedilol Immunosu...

NURS 531EXAM 1 Notes 1. More drugs metabolized by CYP3A4 greater than any other P450 enzyme = increased drug-drug interaction 2. Factors that regulate Css (serum conc), with this ADME is same to c heck maintenance dose = increase drug increase Css plasma levels 3. Induction of CYP450 Enzyme >>> increased # of enzymes, increased intrinsic? activity increased rate of metabolism = increase metabolic rate >>> decrease amount of purest? drug 4. IV drug 1st order kinetic Q 3hrs. 9 hr...

NAPLEX 2022 Solved 100% Correct!!

NURS 531EXAM 1 Notes 1. More drugs metabolized by CYP3A4 greater than any other P450 enzyme = increased drug-drug interaction 2. Factors that regulate Css (serum conc), with this ADME is same to c hec k maintenance dose = increase drug increase Css plasma levels 3. Induction of CYP450 Enzyme > >> increased # of enzymes, increased intrinsic? activity increased rate of metabolism = increase metabolic rate >>> decrease amount of purest? drug 4. IV drug 1st order kinetic Q 3hrs. 9 ...