Ultrarapid metabolism - Study guides, Class notes & Summaries

A What is the cell that is indicated by the arrow in this field? A. Red cell fragment B. Acanthocyte C. Burr cell D. Crenated cell D A young man is experiencing difficult breathing after fainting. The physician orders a blood gas analysis which shows the following results: pH = 7.25 pCO2 = 62 mmHg pO2 = 70 mmHg HCO3 = 23 mEq/L Which condition is most likely afflicting this patient? A. metabolic alkalosis B. metabolic acidosis C. respiratory alkalosis D. respir...

RNFA MASTER 2023/2024 QUESTION AND CORRECT ANSWER Neuromuscular blockers - CORRECT ANSWER-Tubocurarine Atracurium Cisatracurium Mivacurium Rocuronium Pancuronium Vecuronium Succinylcholine AchE inhibitors - CORRECT ANSWER-Neostigmine Edrophonium Muscarinic Antagonists - CORRECT ANSWER-Glycopyrrolate Spasmolytics - CORRECT ANSWER-Dantrolene Diazepam Baclofen Tizanidine Gabapentin Progabide Glycine Idrocilamide Riluzole Dantrolene Botulinum toxin Cyclobenzaprine Neuromuscular blockers...

Pharmacokinetics vs pharmacodynamics definitions PK - what the body does to the drug (drug, conc) - use concentration/time - the study of time-course of drug concs in body and factors affecting this PD - what the drug does to the body (effects) - use response/concentration - the study of drug effects and moa Possible reasons for overdose of a drug (exceeding maximum toxic conc) renal impairment reduced metabolism - liver imp - enzyme inhibition - pharmacogenetics Possible reasons ...

Medicinal Chemistry, Exam Elaboration 2024. Lipinski's Rules - Indicate: An orally active drug should have the following: No more than 5 hydrogen bond donors No more than 10 hydrogen bond acceptors A molecular weight under 500 Da An octanol-water partition coefficient less than 5 First Pass Effect - Indicate: When the majority of the active drug is metabolized the first time it goes through the liver(majority done here), gut wall, or portal vein. This necessitates that the drug must e...

Pharm Phlashcards (Latest update) Aspirin - (ASA) NSAID, Poor po metabolism, acidic, zero order elimination, cyp2c9, irreversibly binds platelets; low doses: Anti-platelet (TIAs, stroke, MI prophylaxis), intermediate doses: Analgesic; Anti-pyretic (medium to low grade fevers), high doses: Anti-inflammatory (arthritis, joint swelling); SE: gi mucosal damage, bleeding, allergic rxn, Reye's syndrome Reye's Syndrome - febrile viral illness in children under 16 + ASA = persistent vomiting...

Prodrug ● A compound that is inactive when administered and converts to active form via metabolism Active drug ● Administered as active and is inactivated when metabolized. 4 Phenotypes of Metabolizers ● UM: Ultrarapid responders ○ Active drugs: ineffective ○ Prodrug: toxic ● EM: Extensive Responders ○ Active drug & prodrug: possibly therapeutic ● IM: Intermediate Responders ○ Active drug & prodrug: possibly therapeutic ● PM: Poor Responders ○ Active drug: tox...

NR 565 week 1 completed study guide Many questions are written to assess your clinical application of the material from the textbook, in real-world scenarios. Chapter 2: Review of Basic Principles of Pharmacology How new drugs are developed : the early part of the drug development process is called the preclinical stage. Identification of promising drugs and their testing in animals occur during this stage. Pharmaceutical companies will identify a drug target, starting sometimes w...

Chapter 8 An Introduction to Pharmacogenomics  Optimal drug treatment requires selection of the best possible agents with close monitoring of pharmacokinetics, pharmacodynamics, adverse drug rea ctions, and the cost of different agents.  Pharmacogenomics is the branch of science concerned with the identification of the genetic attributes of an individual that lead to variable responses to drugs. Interestingly, the science has evolved to also consider patterns of inherited alterations in de...

Chapter 7 Cultural and Ethnic Influences in Pharmacotherapeutics U.S. Demographics  Consistent with the growth of the foreign-born population is the growth in the number of people who have limi ted English proficiency (LEP), defined by the U.S. Census Bureau as any person age 5 and over who reported speaking English “less than very well.”  Being in the LEP category and having minority status have been shown to be risk factors for low health literacy. These factors make it difficult for...