Wnt pathway - Study guides, Class notes & Summaries

GPCRs, kinases, hallmarks of cancer, cancer genomics (I & II), the cell cycle, checkpoints, p53 pathway, tgf-beta, angiogenesis, metastasis, invasion, tumor suppression, WNT signaling, pocket proteins, MPS (massively parallel sequencing), NGS (Next generation sequencing),

This study guide provides a comprehensive overview of key cell signaling pathways, including GPCR, Receptor Tyrosine Kinase (RTK), Wnt, and Notch cascades. It covers the molecular mechanisms involved in each pathway, highlighting important signaling molecules, protein interactions, and downstream effects. Additionally, the guide explores concepts such as transcription factor activation, proteolytic cleavage, and the role of beta-catenin and the proteasome in signal transduction.

Quiz questions based on Lecture 13 (Signaling-1). 1. What is always present in a signaling pathway? A. Signal that originates outside a cell B. Signal that remains outside the responding cell during signaling C. Cell-surface receptor D. A and B are correct 2. Adrenaline is a signal used in the fight-or flight response. Adrenaline signaling is A. Endocrine B. Paracrine C. Autocrine D. Contact-dependent 3. One signal can have different effects on the same cell; for example, it can alter...

Summary that includes all lectures given by Schuringa, Van Vught, Kruyt and de Jong.The topics of the lectures are: carcinogenesis, cancer stem cells, the role of oncogenes and tumor suppressor genes, the large variety of subtypes within hematological and solid tumors, the signaling pathways active in different tumor types, genetic regulation of these molecular pathways (epigenetics, miRNA), DNA damage response, the tumormicroenvironment , the process of metastasis, tumor immunology, therapeutic...

Question 1 2 out of 2 points In which of these conditions would you expect an elevation of p53 expression in normal cells? Selected Answer: All of these  Question 2 0 out of 2 points Which of these TSGs plays an important role in the direct inactivation of a GTPbound Ras oncogene and when it is mutated can result in sporadic sarcomas in affected patients? Selected Answer: [None Given]  Question 3 0 out of 2 points In a patient with a constitutively active receptor tyrosin...

BIOM 500 QUIZ 3 PRACTICE NEW UPDATED EXAM QUESTIONS AND ANSWERS 1. Terminally differentiated cells go into the quiscent stage of the cell cycle also described as G0 Phase G1 Phase G2 Phase S phase 2. Cancer cells actively duplicate their genetic material in the stage of the cell cycle called; S Phase M Phase G1 Phase G2 Phase 3. Cyclin-dependent kinase 6 exerts its cell cycle progression effects by acting on these substrates except; Rb SMAD2 P130 p53 4. An inhibition of...

MOLECULAR BIOLOGY OF HUMAN CANCERS. What is commonly called ‘human cancer’ comprises in fact more than 200 different diseases. Together, they account for about one fifth of all deaths in the industrialized countries of the Western World. Likewise, one person out of three will be treated for a severe cancer in their life-time. In a typical Western industrialized country like Germany with its 82 million inhabitants, >400,000 persons are newly diagnosed with cancer each year, and |200,0...

12 Page summary of main topics in cell signalling. Contents: Wnt signalling 1 Canonical (Wnt/Catenin) and Non-canonical (Wnt/Planar Cell Polarity and Wnt/Ca2+ Signalling) pathways 1 GRB2 and the activation of the MAP Kinase cascade 2 Insulin receptor 2 The regulation of cell polarity 3 The molecular basis of vision in the rod cells and Rhodopsin-mediated signalling. 4 JAK-STAT Signalling 5 Insulin Receptor 6 Transforming growth factor-β (TGFβ) 7 The Estrogen Receptor 8 GPCR’s ...

This summary contains all the cases and lectures of BBS-1005: Genetics, reproduction and prenata. The summary contains a lot of detail, clear explanations, nice pictures and schemes. The following topics are covered: Gametogenesis, meiosis, DNA, RNA, mutations, gamete quality, DNA repair mechanisms, embryonic development, fertilization, implantation, cleavage, embryonic stem cells, IVF, PDG, Gene regulation, transcriptional control, post-translational modifications, Drosophila, Segmentation, t...