Gms 6504 exam 2024 - Study guides, Class notes & Summaries

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GMS 6504 MODULE 1-3 Exam 1 Questions with 100% Correct Answers | Latest Version 2024 | Expert Verified | Ace the Test

GMS 6504 MODULE 1-3 Exam 1 (2024) Questions With Complete

GMS 6504 MODULE 1-3 Exam 1 Questions With 100% Verified Answers What are System Independent Parameters? - answerAffinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - answerNumber of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - answerThermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - answerMagnitude of change of receptor shape/function upon drug bi...

Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) - Log10(P) Improved Lipinski Parameters - ANSWER-1. Partition...

What are System Independent Parameters? - ANSWER-Affinity Efficacy What are the parts of a system that are identified as System Dependent Parameters? - ANSWER-Number of receptors Cellular machinery Presence of other drugs - Competitive - Noncompetitive Affinity is - ANSWER-Thermokinetic propensity of drug to bind to receptor Based largely on ΔG Efficacy is - ANSWER-Magnitude of change of receptor shape/function upon drug binding Based on atom/atom interactions What i...