Lipinskis rule of 5 - Study guides, Class notes & Summaries

GMS6504 #2 Questions And Answers With Verified Solutions what are the four things that make a good drug versus a bad one? 1. Lipinski's Rule of 5 2. Chemical reactivity: good or bad? 3. Some chemically or biologically reactive functional groups to recognize 4. Choosing a target explain the old lipinskis rule of 5 and the rules Poor absorption or permeation are more likely when: 1. Molecular mass greater than 500 Da (want small and absorbable) 2. High lipophilicity (expressed as LogP...

GMS6504/GMS 6504 University Of Florida -GMS 6504 CHAPTER 4 Questions With Complete Solutions

GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equili...

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Lipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equilibrium concentrations of dissolved substance in a two-phase system containing two largely immiscible solvents (water & octanol) - Log10(P) Improved Lipinski Parameters - ANSWER-1. Partition...

GMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectGMS 6504 Exam Questions and Answers 100% CorrectLipinski's rule of 5 - ANSWER-- Poor absorption or permeation are more likely when: 1. mass greater than 500 Da 2. highly lipophilic - logP > 5 3. more than 5 hydrogen bond donors 4. more than 10 hydrogen bond acceptors Partition coefficient - ANSWER-p = C(octanol)/C(water) - ratio of the equili...

Lipinski's Rule of 5 - ANSWER-A successful drug meets these criteria: -LogP<5 -molecular weight <500 g/mol - hydrogen bond donors <5 -hydrogen bond acceptors <10 -rotatable bonds<10 logD - ANSWER-distribution between all forms of drug (logD<5) Polar surface area - ANSWER-the surface area of nitrogen's, oxygens, and their attached protons on a molecule What is the problem with Lipinski's rules - ANSWER-the majority of drugs that are being focused on only adhere ...

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