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What bond does ace cleave - Study guides, Class notes & Summaries

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CORE EXAM 1 Q&A

  • CORE EXAM 1 Q&A

  • Exam (elaborations) • 4 pages • 2023
  • What bond does RENIN cleave? - Answer- Leu-Val peptide bond in Angiotensinogen What bond does ACE cleave? - Answer- Phe-His peptide bond in Angiotensin 1 Enalapril Prodrug Approach - Answer- Adds a ester to lower the pKa of the NH group and removes the charge of the free COOH ACE Nonspecific or Specific? - Answer- NONSPECIFIC enzyme therefore it hydrolyzes peptides of similar structure (bradykinin, substance P, enkephalins) RENIN - Answer- Highly specific aspartyl proteinase. produce...
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