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Paroxetine’s Pharmacokinetic and Pharmacodynamic Factors
Paroxetine is characterized as an antidepressant whose properties are induced by selective inhibition of serotonin uptake. The phenylpiperidine (trans-isomeric) has a low affinity for receptors – muscarinic receptors – translating to non-direct interaction with monoamine receptors which are also neurotransmitters. Paroxetine is actively absorbed in the gastrointestinal tract and undergoes a first pass metabolism leading to its reduced bioavailability. After transformation (in the liver), par...
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Paroxetine is characterized as an antidepressant whose properties are induced by selective inhibition of serotonin uptake. The phenylpiperidine (trans-isomeric) has a low affinity for receptors – muscarinic receptors – translating to non-direct interaction with monoamine receptors which are also neurotransmitters. Paroxetine is actively absorbed in the gastrointestinal tract and undergoes a first pass metabolism leading to its reduced bioavailability. After transformation (in the liver), par...