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Naive Bayes, Laplace Smoothing summary
Outline 
Naive Bayes 
Laplacesmoothing 
Event Models 
Kernel Methods
- Package deal
- Summary
- • 7 pages •
Outline 
Naive Bayes 
Laplacesmoothing 
Event Models 
Kernel Methods
Gaussian discriminant analysis. Naive Bayes.
Gaussian discriminant analysis & it is model 
Naive Bayes.
- Package deal
- Summary
- • 6 pages •
Gaussian discriminant analysis & it is model 
Naive Bayes.
Gaussian discriminant analysis. Naive Bayes.Laplace Smoothing.
Generative Learning algorithms 
Gaussian discriminant analysis. 
Naive Bayes. 
Laplace Smoothing.
- Package deal
- Class notes
- • 14 pages •
Generative Learning algorithms 
Gaussian discriminant analysis. 
Naive Bayes. 
Laplace Smoothing.
Linear Algebra
Outline 
1 Basic Concepts and Notation 
2 Matrix Multiplication 
3 Operations and Properties 
4 Matrix Calculus
- Package deal
- Presentation
- • 29 pages •
Outline 
1 Basic Concepts and Notation 
2 Matrix Multiplication 
3 Operations and Properties 
4 Matrix Calculus
Linear Algebra Review
Contents 
1 Basic Concepts and Notation 2 
1.1 Basic Notation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 
2 Matrix Multiplication 3 
2.1 Vector-Vector Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 
2.2 Matrix-Vector Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 
2.3 Matrix-Matrix Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 
3 Operations and Properties 7 
3.1 The Identity Matrix and Diagonal Matric...
- Package deal
- Class notes
- • 94 pages •
Contents 
1 Basic Concepts and Notation 2 
1.1 Basic Notation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 
2 Matrix Multiplication 3 
2.1 Vector-Vector Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 
2.2 Matrix-Vector Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 
2.3 Matrix-Matrix Products . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 
3 Operations and Properties 7 
3.1 The Identity Matrix and Diagonal Matric...
Dataset split; Exponential family. Generalized Linear Models.
Perception 
Exponential Family Generalized Linear Models 
Soft max Regression Multiclass Classification
- Package deal
- Summary
- • 8 pages •
Perception 
Exponential Family Generalized Linear Models 
Soft max Regression Multiclass Classification
Supervised learning setup
Supervised learning 
Linear Regression 
1 LMS algorithm 
 
2 The normal equations 
2.1 Matrix derivatives 
3 Probabilistic interpretation 
and more
- Package deal
- Class notes
- • 28 pages •
Supervised learning 
Linear Regression 
1 LMS algorithm 
 
2 The normal equations 
2.1 Matrix derivatives 
3 Probabilistic interpretation 
and more
computational biology overview
• Atomic-level modeling of biological macromolecules 
– Energy functions and their relationship to molecular conformation 
– Molecular dynamics simulation 
– Protein structure prediction 
– Protein design 
– Ligand docking 
• Coarser-level modeling and imaging-based methods 
– Fourier transforms and convolution 
– Image analysis 
– Microscopy 
– X-ray crystallography 
– Cryoelectron microscopy 
– Diffusion and cellular-level simulation 
• Recurring themes
- Summary
- • 72 pages •
• Atomic-level modeling of biological macromolecules 
– Energy functions and their relationship to molecular conformation 
– Molecular dynamics simulation 
– Protein structure prediction 
– Protein design 
– Ligand docking 
• Coarser-level modeling and imaging-based methods 
– Fourier transforms and convolution 
– Image analysis 
– Microscopy 
– X-ray crystallography 
– Cryoelectron microscopy 
– Diffusion and cellular-level simulation 
• Recurring themes
intro to cryo-electron microscopy
is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures and embedded in an environment of vitreous water. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane.[2] While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the determination of biomolecular structures at near-atomic resolution.[3] This has attracted wide ...
- Class notes
- • 69 pages •
is a cryomicroscopy technique applied on samples cooled to cryogenic temperatures and embedded in an environment of vitreous water. An aqueous sample solution is applied to a grid-mesh and plunge-frozen in liquid ethane or a mixture of liquid ethane and propane.[2] While development of the technique began in the 1970s, recent advances in detector technology and software algorithms have allowed for the determination of biomolecular structures at near-atomic resolution.[3] This has attracted wide ...
Computational Biology exam + answers
Test Details 
The exam will be held on Friday, December 10, 2021 from 3:30 PM PM - 6:30 PM (in 320-105). The 
exam will be closed-book, but you may consult one double-sided 8.5x11 page (or two single-sided 
pages). 
Instructions 
These are practice questions in the style of questions you might expect on the exam. Each question 
should be answerable in a few sentences (that is, you’re not required to provide a great deal of 
detail). 
Question 1: Compare and contrast the energy functions used f...
- Exam (elaborations)
- • 3 pages •
Test Details 
The exam will be held on Friday, December 10, 2021 from 3:30 PM PM - 6:30 PM (in 320-105). The 
exam will be closed-book, but you may consult one double-sided 8.5x11 page (or two single-sided 
pages). 
Instructions 
These are practice questions in the style of questions you might expect on the exam. Each question 
should be answerable in a few sentences (that is, you’re not required to provide a great deal of 
detail). 
Question 1: Compare and contrast the energy functions used f...