i iii 1. iA ipatient’s inutritional iintake iand ilaboratory iresults ireflect ihypoalbuminemia. iThis iis icritical ito
iprescribing ibecause:
1. Distribution iof idrugs ito itarget itissue imay ibe iaffected.
2. The isolubility iof ithe idrug iwill inot imatch ithe isite iof iabsorption.
3. There iwill ibe iless ifree idrug iavailable ito igenerate ian ieffect.
4. Drugs ibound ito ialbumin iare ireadily iexcreted iby ithe ikidneys.
i iii 2. iDrugs ithat ihave ia isignificant ifirst-pass i effect:
1. Must ibe igiven iby ithe ienteral i(oral) iroute ionly
2. Bypass ithe ihepatic icirculation
3. Are irapidly imetabolized iby ithe iliver iand imay ihave ilittle iif iany idesired iaction
4. Are iconverted iby ithe iliver ito imore iactive iand ifat-soluble iforms
i iii 3. iThe iroute iof iexcretion iof ia ivolatile idrug iwill ilikely ibe ithe:
1. Kidneys
2. Lungs
3. Bile iand ifeces
4. Skin
i iii 4. iMedroxyprogesterone i(Depo iProvera) iis iprescribed iintramuscularly i(IM) ito icreate ia istorage
ireservoir iof ithe idrug. iStorage ireservoirs:
1. Assure ithat ithe idrug iwill ireach iits iintended itarget itissue
2. Are ithe ireason ifor igiving iloading idoses
3. Increase ithe ilength iof itime ia idrug iis iavailable iand iactive
4. Are imost icommon iin icollagen itissues
i iii 5. iThe iNP ichooses ito igive icephalexin ievery i8 ihours ibased ion iknowledge iof ithe idrug’s:
1. Propensity ito igo ito ithe itarget ireceptor
2. Biological ihalf-life
3. Pharmacodynamics
4. Safety iand iside ieffects
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