Exam (elaborations)
Hbss Sickle Cell Disease And Anesthesia Questions And Answers Well Elaborated Rated A+
- Course
- Institution
Hbss Sickle Cell Disease And Anesthesia Questions And Answers Well Elaborated Rated A+
[Show more]
Seller
Follow
classhub
Reviews received
Content preview
Hbss Sickle Cell Disease AndAnesthesia Questions And Answers Well
Elaborated Rated A+
definition of sickle cell disease - ANSWER✔✔ a genetic disorder resulting from the
presence of a mutated form of hemoglobin (HbS). the most common form of SCD
is homozygous HbS disease (HbSS) causing significant morbidity and mortality in
African and mediterranean ethnicities
structure of hemoglobin - ANSWER✔✔ alpha globulin protein
made up of heme and globin
What is heme and what is globin? - ANSWER✔✔ heme: the iron containing part of
the molecule
globin: the protein part of the molecule
what are the 3 normal types of hemoglobin - ANSWER✔✔ HbA- 2 alpha, 2 beta
HbF- 2 alpha, 2 gamma
HbA2- 2 alpha, 2 delta
pathophys of sickle cell disease - ANSWER✔✔ in HbS, valine is substituted for
glutamic acid in the 6th amino acid on the beta chain
upon deoxygenation, HbS undergoes polymerization which causes sickling
how does HbS affect the RBC - ANSWER✔✔ rbc survival reduced to 10-15 days,
instead of the normal 120 days
, HbS has less affinity for oxygen as well as decreased solubility
sickle shaped RBCs cause vaso-occlusive crises leading to infarct
sickling may initially be reversible but becomes irreversible
types of sickle cell disease - ANSWER✔✔ Sickle cell SS
Sickle cell SC
Sickle cell trait
sickle cell SS (HbSS) - ANSWER✔✔ homozygous form of hemoglobin S disease
sickle cell SC (HbSC) - ANSWER✔✔ HbC inherited from one parent, and HbS
inherited from the other
similar s/s to individuals with HbSS but anemia is less severe
sickle cell trait - ANSWER✔✔ heterozygous form of Hb S
patients are generally not anemic, are asymptomatic, and have a normal life span
SCD and CNS - ANSWER✔✔ stroke, cranial nerve neuropathy, peripheral
neuropathy
SCD and opthal - ANSWER✔✔ sickle retinopathy
SCD and pulmonary - ANSWER✔✔ infarct, pneumonia, acute chest syndrome
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through EFT, credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying this summary from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller classhub. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy this summary for R213,45. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
75759 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy summaries for 14 years now