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BIOS 255 Week 7 Case Study-Carbon Monoxide Poisoning

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BIOS 255 Week 7 Case Study-Carbon Monoxide Poisoning 1.Question: With respect to hemoglobin loading, please explain the relationship between binding of oxygen (O2) and carbon monoxide (CO) to the hemoglobin molecules. 2.Question: During the ambulance ride, a pulse oximeter showed 100% O2 satu...

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  • 23 de marzo de 2022
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Week 7 Case Study: Carbon Monoxide Poisoning

BIO255: Anatomy & Physiology III w/Lab

, 2


1. With respect to hemoglobin loading, please explain the relationship between the

binding of oxygen (O2) and carbon monoxide (CO) to the hemoglobin molecules.


The hemoglobin molecule has four binding sites for oxygen molecules: the iron atoms in

the four heme groups. Thus, each Hb tetramer can bind four oxygen molecules. From the

molecular weight of Hb, one can calculate that 1 g of Hb can combine with 1.39 ml of

oxygen. Meanwhile, carbon monoxide is dangerous for several reasons. When CO binds

to one of the binding sites on hemoglobin, the increased affinity of the other binding sites

for oxygen leads to a left shift of the oxygen dissociation curve. Thus, it interferes with

the unloading of oxygen in the tissues. Carbon monoxide prevents the loading of oxygen

due to competition for the same binding sites, thereby showcasing how they relate. This

shift prevents oxygen unloading in peripheral tissue, and therefore the oxygen

concentration of the tissue is much lower than normal. Thus, in the presence of carbon

monoxide, a person can experience severe tissue hypoxia while maintaining a normal

PaO2. For instance, patients with Carbon-monoxide poisoning experience headaches,

malaise, altered mental status, shortness of breath, seizures, or cherry red lips.


2. During the ambulance ride, a pulse oximeter showed 100% O2 saturation. Why

is that different from the 72% measured at the hospital?


The pulse oximeter uses a cold light source that shines a light through the fingertip,

making the tip appear red. By analyzing the light source that passes through the finger,

the device can determine the percentage of oxygen in the red blood cell. Thereby, in

cases of carbon monoxide poisoning, it shows 100% Oxygen saturation because the

device cannot distinguish between the color of carboxyhemoglobin and oxyhemoglobin.

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