Class Notes Pulmonary Vasculitis and Respiratory Pharmacology

■ GPA vs MP
Pulmonary Vasculitis Polyangii
ANCA; Mi
★ Vasculitis - inflammation of blood vessels; Vasculitides - its diseases
■ GPA - can
○ Primary:
imaging.
■ Large
■ EGPA - ch
■ Medium
ground-g
■ Small
■ DLCO - di
○ Secondary:
impractica
■ Infection
■ Drug reactions
■ Connective tissue disease
■ Malignancy
★ Classification of Vasculitides:




■ A - CT sho
consolida
pulmonar
alveolar se
○ Bronchoscopy wit
cytology - possibl
★ Diffuse Alveolar Hem
○ Life-threatening
○ Poor prognosis, in
○ Usually diffuse, ca
○ Classification:
■ Immune:
■ Congestiv
★ Pulmonary Vasculitis ■ Miscellan
○ Lung involvement in: drugs
■ Primary, idiopathic, small-vessel → Antineutrophil ■ Idiopathic
cytoplasmic antibody-associated vasculitides
● Wegener’s granulomatosis
● Microscopic polyangiitis
● Churg-Strauss syndrome → EGPA
■ Primary, idiopathic medium and large-vessel vasculitis →
primary immune complex-mediated vasculitis
■ Secondary vasculitis
○ Rare, incidence = 20-100/mln, prevalence = 150-450/mln
○ Small vessels affected - capillaries, also arterioles, venules
○ Small-vessel vasculitides:
■ Antineutrophil cytoplasmic antibody - ANCA associated
vasculitides - AAV
■ Immune-complex mediated vasculitides
○ Component of Systemic vasculitis
○ Vasculitides - difficult diagnosing
○ Signs/symptoms - overlap with infection, tumor, thromboembolic
disease, connective tissue diseases
○ Etiology of AAV - it is autoimmune so unknown