, Questions 1-10: Choose one best response from several for each set of questions
Question 1 Which one of the following is not true with regard to tumour
suppressor genes?
A. P53 is a tumour suppressor gene
B The wild-type is the mutant variant of the gene
C Rb gene mutation is only seen in retinoblastoma
D BRCA1 mutation is associated with breast cancer
E Homozygous mutations are more significant than heterozygous
mutations
Question 2 Which one of the following lung diseases is not associated with
granulomatous inflammation?
A. Histoplasmosis
B. Extrinsic allergic alveolitis
C. Myobacterial infection
D. Mycoplasma infection
E. Sarcoidosis
Question 3 Which one of the following best describes anaplasia?
A. Carcinoma in-situ
B. Transformation from one cell type to another
C. Growth of a normal tissue in an abnormal place
D. Growth which closely resembles normal tissue
E. Growth resulting in a tissue with no resemblance to the tissue of origin
Question 4 Which one of the following is false with regard to pneumonia?
A. Aspiration pneumonia is associated with anaesthesia
B. Hypostatic pneumonia is associated with prolonged bed rest
C. Nosocomial pneumonia is acquired in the community
D. Bronchopneumonia is a disease of the extremes of life
E. Atypical pneumonia may be due to Mycoplasma
Question 5 Which one of the following best describes ‘metastatic calcification’?
A. Calcification of a tissue in which no cause can be found
B. Calcification of a tissue which has been previously damaged
C. Calcification due to a persistent elevation in serum calcium
D. Calcium deposits which have broken off from a bone and spread to
other sites
E. Calcification within a tumour metastasis
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