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Targeting cellular processes to treat disease - Everything you need to know
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MERU UNIVERSITY OF SCIENCE AND TECHNOLOGYP.O. Box 972-60200 – Meru-Kenya.
Tel: +254(0) 799 529 958, +254(0) 799 529 959, +254 (0)712 524 293
Website: www.must.ac.ke Email: info@mucst.ac.ke
UNIVERSITY EXAMINATIONS 2021/2022
FIRST YEAR, FIRST SEMESTER EXAMINATION FOR DEGREE OF BACHELOR OF
SCIENCE IN CLINICAL MEDICINE AND COMMUNITY HEALTH
CCM 3112: MEDICAL BIOCHEMISTRY I
DATE: JANUARY 2022 TIME: 2 HOURS
INSTRUCTIONS: Answer all questions in the booklet provided
Ensure that all your answers are properly numbered
Part I: Short Answer Questions-Answer questions following each other
on the answer booklet
Part II: Long Answer Questions-Answer the questions on the answer
booklet.
Part III: Multiple Choice Questions (MCQs): Write the correct answer on
the space provided in the answer booklet. Each MCQ is one mark.
SECTION ONE (SHORT ANSWER QUESTIONS, 20 MARKS)
1. Draw the chemical structure of a dipeptide (5 Marks)
2. Describe the factors that affect enzyme activity (5 Marks)
3. Compare and contrast DNA replication and transcription processes (5 Marks)
4. Explain the application of enzymes in diagnosis and treatment (5 Marks)
SECTION TWO (LONG ANSWER QUESTIONS, 30 MARKS)
1. Discuss the sources DNA damage and how they can be repaired (10 Marks)
2. Explain the protein structure function relationship using sickle cell disease as an example.
(10 Marks)
3. Write short notes on application of biomolecules in diagnosis and treatment. (10 Marks)
Meru University of Science & Technology is ISO 9001:2015 Certified
Foundation of Innovations Page 1
, SECTION THREE (MULTIPLE CHOICE QUESTIONS, 20 MARKS)
1. When myocardial infaction happens, the following cardiac enzyme will be elevated first
a. Acid phosphate
b. Amylase
c. Creatine Kinase
d. Alanine Aminotransferase
e. Trypsin
2. UV light from the sun is one of the sources of DNA damage. The following are used to
repair DNA damage caused by UV light
a. DNA polymerase
b. Ligase
c. Glycosylase
d. Exonuclease
e. Helicase
3. Sickle cell disease is predominantly found in malaria endemic regions. The following
statements describe the disease
a. The red cells assume a cresent shape
b. Amino acid change from glutamic acid to valine
c. Impaired transport of oxygen
d. Amino acid change from valine to glutaminc acid
e. It is inherited
4. The following describes point maturations which do not change the amino acid sequence
a. Missense mutations
b. Nonsense mutations
c. Active mutations
d. Silent mutations
e. Frameshift mutations
5. The following bases are classified as purines
a. Thymine
b. Uracil
c. Cytosine
d. Guanine
e. Adenine
Meru University of Science & Technology is ISO 9001:2015 Certified
Foundation of Innovations Page 2
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