100% de satisfacción garantizada Inmediatamente disponible después del pago Tanto en línea como en PDF No estas atado a nada
logo-home
Buscado previamente por ti
Buscado previamente por ti
logo
Intermediate Pharmacology (PHAR0009) Notes - Receptors and Signalling 7,92 €
Añadir al carrito
Navegar rápidamente a
Vista previa
  2.  
  3. University College London (UCL)
  4.  
  5. Intermediate Pharmacology (PHAR0009)

Notas de lectura

Intermediate Pharmacology (PHAR0009) Notes - Receptors and Signalling
 0 veces vendidas
  • Grado
  • Intermediate Pharmacology (PHAR0009)
  • Institución
  • University College London (UCL)

Explore Intermediate Pharmacology at UCL with a focus on the Receptors and Signalling chapter. Delve into the realm of agonists, drugs, and the intricate structure of receptors. Unravel the complexities of cellular signaling and signal transduction. Please note that these materials are intended for...

[Mostrar más]

Vista previa 2 fuera de 14  páginas

Información del documento

  • 1 de diciembre de 2023
  • 14
  • 2021/2022
  • Notas de lectura
  • Dr talvinder sihra
  • Todas las clases

Temas

  • agonists
  • drugs
  • receptor structure
  • receptors
  • signalling
  • signal transduction

Escuela, estudio y materia

  • University College London (UCL)
  • Desconocido
  • Intermediate Pharmacology (PHAR0009)
Todos documentos para esta materia (3)

Vendedor

avatar-seller
sujansathiendran

Comentarios recibidos

Vista previa del contenido

Receptors and Signalling – Summary
Introduction
 Pharmacology – the study of drugs
o Naming of drugs + targets of drug action + selectivity of drugs + measuring ratio of beneficial to
unwanted effects
 Naming drugs
o Classification according to:
 Therapeutic use
 Molecular mechanism of action
 Chemical structure
o Approved name + brand name
 Targets of drug action
o Selective toxicity
 Drugs bind to other sites of action in addition to main site  resulting in unwanted effects
o Magic bullet
 Drug might act selectively at intended site of action
 Has high affinity for cell – only targets main site by aiming with specific chemicals
 Has little effect for organism – minimising damage
 Selectivity of drugs
o Pharmacokinetics – drug motion
 Study of time course of drug absorption + distribution + metabolism + excretion
 Aim to achieve a higher concentration of drug at desired site of action
o Pharmacodynamics – drug power
 Study of biochemical and physiological effects of drugs
 Design drug to have a higher affinity for desired site of action
o Drug targets
 Action at a specific binding site
 Specific macromolecular targets may have high affinity for drug + high specificity –
due to stereochemistry of substrate cofactor binding
o Hormone / neurotransmitter receptors – antagonists or agonists
o Enzymes
o Transporters
o Ion channels
o DNA
 Action not involving a specific binding site
 Drug without identifiable binding site – acts at higher concentrations
o Action of drug is less affected by changes in chemical structure
 Measuring ratio of beneficial to unwanted effects of drugs
o Amount of risk acceptable – influenced by severity of medical condition
o Ehrlick’s therapeutic index
 Ehrlick’s therapeutic index = maximum non-toxic dose / minimum effective dose
 Has difficulties with measurements – due to individual variations to drug
o Therapeutic index – uses better defined doses producing effects in
50% of subjects
 Therapeutic index = TD50 / ED50 = toxic dose / effective dose
 Dose response curve
o Toxicity
 In animal studies – death can be used as a measure of
toxicity
 Therapeutic index = LD50 / ED50 = lethal dose / effective dose

, Receptors and Signalling – Summary
Receptor Structure
 Receptors = protein involved in mediating the effects of intercellular signalling molecules
o Site of action of: neurotransmitters + hormones + growth factors + other intercellular signalling
molecules
o Four structurally distinct families
 Transmembrane receptors
 Ligand-gated ion channels (LGICs)
 G-protein-coupled receptors (GPCRs)
 Kinase-linked and related receptors
 Intracellular receptors
 Nuclear receptors

Ligand-Gated Ion Channels – LGICs
 Ligand-gated ion channels – AKA
o Agonist-activated ion channels
o Neurotransmitter-gated ion channels
o Ionotropic receptors
 Structure
o Multi-subunit (oligomeric) transmembrane proteins – contain a central integral ion channel
 Multiple subunits co-assemble with each other  forming a ring-like structure
 Pentameric – 5 complexes
o nAChRs
o GABAARs
o GlyRs
o 5-HT3Rs
 Tetrameric – 4 complexes
o GluRs
 Trimeric – 3 complexes
o ATP(P2X)Rs
o Extracellular agonist binding site – linked by conformational change to narrow portion of channel
located within lipid bilayer = channel gate
o Neurotransmitter bind to site on extracellular domain  causing conformational change  opening
integral ion channel (excitatory or inhibitory)
 Cation channel = excitatory – causes membrane depolarisation
 Acetylcholine (ACh)
o Nicotinic acetylcholine receptor (nAChR)
 5-hydroxytryptpamine (5-HT)
o 5-HT(serotonin) type 3 receptor (5-HT3R)
 Glutamate (Glu)
o Glutamate receptor (GluR)
 Adenosine triphosphate (ATP)
o ATP (P2X) receptor
 Anion channel = inhibitory – causes membrane hyperpolarisation
 g-aminobutyric acid (GABA)
o GABAA receptor (GABAAR)
 Glycine (Gly)
o Glycine receptor (GluR)
o Subunit structure
 Pentameric LGICs
 Each of the 5 subunits are a single polypeptide

Los beneficios de comprar resúmenes en Stuvia estan en línea:

Garantiza la calidad de los comentarios

Garantiza la calidad de los comentarios

Compradores de Stuvia evaluaron más de 700.000 resúmenes. Así estas seguro que compras los mejores documentos!

Compra fácil y rápido

Compra fácil y rápido

Puedes pagar rápidamente y en una vez con iDeal, tarjeta de crédito o con tu crédito de Stuvia. Sin tener que hacerte miembro.

Enfócate en lo más importante

Enfócate en lo más importante

Tus compañeros escriben los resúmenes. Por eso tienes la seguridad que tienes un resumen actual y confiable. Así llegas a la conclusión rapidamente!

Preguntas frecuentes

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

100% de satisfacción garantizada: ¿Cómo funciona?

Nuestra garantía de satisfacción le asegura que siempre encontrará un documento de estudio a tu medida. Tu rellenas un formulario y nuestro equipo de atención al cliente se encarga del resto.

Who am I buying this summary from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller sujansathiendran. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy this summary for 7,92 €. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

45,681 summaries were sold in the last 30 days

Founded in 2010, the go-to place to buy summaries for 15 years now

Empieza a vender

Vistos recientemente

Resumen ·

(0)

ECG basis principes en voorbeelden van de frequenste aandoeningen

Examen ·

(0)

QMA State test Questions and Answers (100% Verified Solutions) 2024.

Examen ·

(0)

NURS 6531N Midterm Exam – Adv. Practice Care of Adults LATEST UPDATE

Examen ·

(0)

NR 341 Final Exam 2022/2023 Questions with All the Correct Answers

Examen ·

(0)

ATITEAS 7 MATH EXAM RECENTLY UPDATED 2023 WITH COMPLETE SOLUTIONS

Examen ·

(0)

NCCT Medical office billing and coding Exam Questions and Answers

Ensayo ·

(0)

HUMN 303 Week 6 Assignment: Art Creation & Reflection – Photography/Cinema

Examen ·

(0)

NURS 6541 Final Exam Questions and Answers Latest Updated 2024 (Graded A+)

Examen ·

(0)

TEST BANK FOR SUCCESS IN PRACTICAL VOCATIONAL NURSING 9TH EDITION

7,92 €
  • (0)
Añadir al carrito
Añadido