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Heyde syndrome: treat aortic valve disease to stop gastrointestinal bleeding? Lara Waldschmidt1,2 and Moritz Seiffert 1,2* 7,56 €   Añadir al carrito

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Heyde syndrome: treat aortic valve disease to stop gastrointestinal bleeding? Lara Waldschmidt1,2 and Moritz Seiffert 1,2*

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Heyde syndrome: treat aortic valve disease to stop gastrointestinal bleeding? Lara Waldschmidt1,2 and Moritz Seiffert 1,2*

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  • 21 de junio de 2024
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  • 2023/2024
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European Heart Journal (2023) 44, 3178–3180 EDITORIAL
https://doi.org/10.1093/eurheartj/ehad277




Heyde syndrome: treat aortic valve disease to
stop gastrointestinal bleeding?
Lara Waldschmidt1,2 and Moritz Seiffert 1,2
*
1
Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany; and 2DZHK
(German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Germany

Online publish-ahead-of-print 5 July 2023



This editorial refers to ‘Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis’, by L.C.M.J. Golstein et al., https://doi.
org/10.1093/eurheartj/ehad340.



Graphical Abstract


aVWS


HMWM


Aortic stenosis TAVI/SAVR

High shear GIB
stress




Angiodysplasia


Heyde syndrome is the association of aortic stenosis and gastrointestinal bleeding (GIB) from angiodysplasia, accompanied by acquired von Willebrand
syndrome (aVWS) leading to decreased levels of high molecular weight multimers (HMWMs). The development of angiodysplasia in the gastrointestinal
tract remains unclear. Mucosal ischaemia, high shear stress resulting from turbulence caused by the stenotic valve, and the presence of aVWS may be
involved. Aortic valve replacement through surgical replacement (SAVR) or transcatheter aortic valve implantation (TAVI) leads to decreased shear
stress and may resolve GIB through recovery of aVWS and potentially dissolving angiodysplasias.




The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.
* Corresponding author. Tel: +49 40 7410 58206, Fax: +49 40 7410 55310, Email: m.seiffert@uke.de
© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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