Question:
What happens when quinidine and digoxin are combined?
Answer:
Quinidine increases digoxin levels by decreasing excretion or altering
distribution
RISK FOR DIGOXIN TOXICITY (s/s: altered heart rhythm, GI upset)
Question:
At what age can statin drugs be prescribed?
Answer:
Statin drugs are approved in children over age 10
,Question:
What is the Atherosclerotic Cardiovascular Disease Risk Score and when is it
used?
Answer:
The ASCVD Risk Score is a calculator that providers can use to determine a
treatment plan.
Low risk - lifestyle changes
High risk - lifestyle changes & medications
Question:
Exetimibe (Zetia) - what is it and when is it used?
Answer:
Zetia is a CAI (cholesterol absorption inhibitor). It is the most common non-
statin drug prescribed for dyslipidemia. May use if statins not tolerated, have
adverse effects or are contraindicated (ex. pregnancy)
Question:
What is the therapeutic action of organic nitrates for angina?
Answer:
Nitrates act on vascular smooth muscles to cause vasodilation (allows blood
to flow to heart)
,Question:
How would you treat high cholesterol if someone was concerned about or
experiencing side effects? What drug classification would be a good choice?
Answer:
Statins are the most commonly used and they are generally well-tolerated and
side effects are uncommon.
Possible side effects - GI upset, myopathy
Question:
What are contraindications for ranolazine?
Answer:
Ranolazine is used to treat angina. It increases the efficiency of the heart /
decreases oxygen demand.
Ranolazine can increase the QT interval, which can cause dysrhythmias. This
drug is contraindicated in patients with a preexisting QT interval. Also
contraindicated in those with liver impairment and those taking inhibitors
like grapefruit juice.
, Question:
What is the therapeutic effect of calcium channel blockers in stable angina?
Answer:
Calcium channel blockers like Verapamil and Nifedipine relax peripheral
arterioles to decrease after load and decrease oxygen demand by the heart.
Question:
What are pharmacologic and non-pharmacologic treatments for
osteoarthritis?
Answer:
Osteoarthritis is affects the thin lining on the ends of bones that enables
sliding during movements (bones rub, causes pain)
NSAIDs are the first line treatment for osteoarthritis
Low impact exercises
Question:
What are complications from untreated gout?
Answer:
Untreated gout can cause tophi to develop (cluster of uric acid crystals that
present as deformities)
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