ExamI1:INURSI660/INURS660I(New
Update)IPsychopharmacologyIandI
AdvancedIMentalIHealthIGuideIwithIQsI&I
As|I100%ICorrect|IGradeIAI(VerifiedI
Answers)-IMaryville
QUESTION
Quetiapine
Answer::
ProminentIH1Ipotency,ImoreIsedating
SE:Iconstipation,Isedation-
strong,Idizziness,Idrowsiness,IdryImouth,IgenIweakness,Iheadache,Iindigestion,IlowIenergy,Iort
hostaticIhypotension,IweightIgain
Warnings-ICoadministeredIwithIkeotconazoleIresultsIinIincreasedIseroquelIexposure.I
CoadministeredIwithIphenytoinIincreasesItheIoralIclearanceIupItoI5Ifold.I
SuicidalIthoughts/behaviorsIinIYA/adolescents
QUESTION
TheI"Pip"IFamily
Answer::
5HT1aIpartialIagonism,ID2IpartialIagonism,I5HT2aIantagonism,IandI5HT7Iantagonism.
Aripiprazole,IBrexpiprazole
QUESTION
AripiprazoleI(Abilify)
Answer::
AtypicalIantipsychotic
,"3rdIgeneration".ID2IpartialIagonism
ManagementIofIschizophrenia,IandIacuteImanicIorImixedIepisodesIinIbipolarIdisorder.
AdjunctItoItreatIdepressionIorIirritabilityIassociatedIwithIautismI(agesI6-18)
SE:Idizziness,Iinsomnia,Iakasthisia,In/v,IweightIgainI(lessIlikelyItoIcause),IsuppressesIprolactin
IlevelsI
Interactions-IketoconazoleIandIotherI3a4IinhibitorsIincreaseIaripiprazoleIlevels.
MayIincreaseIeffectsIofIantihypertensives
QUESTION
BrexpiprazoleI(Rexulti)
Answer::
GreaterIaffinityIforId2Iblockade
Indications:IschizophreniaIandItreatmentIresistantIdepression
SE:Idizziness,Isedation,Ihypotension,Irestlessness.IhyperglycemiaIandIDKA.
MetabolicIlabsIbefore,ImonitorIBMIIandIlipids
QUESTION
ConventionalIAntipsychotics
Answer::
First-GenerationIdrugIforISchizophrenia
-PureID2Iantagonism
-TreatsIpos.IsymptomsIONLYI(dopamineIreceptors)
-LessIexpensive,ImoreIsideIeffects
Disadvantages:IExtrapyramidalIsideIeffects,IAnticholinergicIsideIeffects,ItardiveIdyskinesia,Ilo
werIseizureIthreshold*
-Chlorpromazine,IHaloperidol,Ithiordazine,Iperphenazine
QUESTION
ChlorpromazineI(Thorazine)
Answer::
, Indications:Ischizophrenia,Ipsychoses,Imanic-
depression,IandIsevereIbehavioralIproblemsIinIchildrenIagesI1-
12.IChlorpromazineIisIalsoIusedItoItreatInauseaIandIvomiting,IanxietyIbeforeIsurgery,IchronicI
hiccups,IacuteIintermittentIporphyria,IandIsymptomsIofItetanus.
SE:Iphotophobia,Ilightheadedness,Idizziness,Idrowsiness,IblurredIvision,IweightIgain,ItroubleIs
leeping
Interactions:IFood,Ialcohol,IandIbenztropineIcanIreduceIabsorption.IAntacidsIcanIslowIabsorpti
on.ILithiumIandIbarbituatesIcanIleadItoIincreasedIclearance.
TCAsIdecreaseIclearance
SeriousIadverseIeffects:IposturalIhypotension,IEKGIchanges,IrespiratoryIdepression
QUESTION
Haloperidol
Answer::
MoreIselectiveIforID2Ireceptor,IlessIanticholinergicIeffects,IlessIantihistamine,IandIanti-
adrenergicIeffect
SE:IEPS,IneurolepticIinducedIsyndrome,Iakathisia,ITDIwithIhighIdoses,Iamenorrhea,Igalactorr
hea
Interactions:IdecreasesIeffectsIofIlevodopa,IdopamineIagonists.I
SeriousIadverseIevents:IIfIgivenIIV,IptIneedsItoIbeIonIcardiacImonitor.ICanIprolongIqtcIinterv
alIandIleadItoItorsadesIandIcauseIsuddenIcardiacIdeath.I
Indications:IacuteIagitation,ITourette's,Idelirium
QUESTION
ThioridazineI(Mellaril)
Answer::
DopamineIreceptorIantagonist.I
SE:IRetinalIdeposits,IRPEIhyperpigmentation,IdryIeye,Imydriasis,IincreasedIIOPI(watchIinInar
rowIangle),Ihypotension,IweightIgainIQTcIprolongation.
Interactions:Ilevodopa,IdopamineIagonists,ICNSIdepressants,Iantihypertensives
Indications:IschizophreniaIptsIwhoIfailItoIrespondItoIotherIantipsychotics.
