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Introduction to Clinical Pharmacology 10th Edition by Constance Visovsky Questions And Correct Answers Verified Latest Guaranteed Pass Grade A + UPDATED!!

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Introduction To Clinical Pharmacology

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introduction to clinical pharmacology 10th edition
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Institución Introduction to Clinical Pharmacology
Grado Introduction to Clinical Pharmacology

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Introduction to Clinical Pharmacology 10th Edition
by Constance Visovsky Questions And Correct
Answers Verified Latest 2024-2025 Guaranteed Pass
Grade A + UPDATED!!

What is the definition of clinical pharmacology? -- CORRECT
ANSWER-->A discipline spanning the spectrum of drug delivery,
drug development, drug utilization, and drug regulation

What are the words for the following blanks?

Clinical Pharmacology is aimed at advancing therapeutics in
humans with mechanistic understanding of drug actions _____
and drug disposition _____ -- CORRECT ANSWER--
>pharmacodynamics and pharmacokinetics

What is the definition of translational sciences? -- CORRECT
ANSWER-->Knowledge acquired in animal or in silico models of
disease, ex-vivo studies in human tissues, or in vivo studies in
healthy or diseased humans is translated into effective
treatment for patients
1
Page

, What is the starting dose of Phase I trial? -- CORRECT ANSWER--
>one tenth of LD50 for cancer or phytotoxins

What are the professional goals of clinical pharmacologists? --
CORRECT ANSWER-->Discover, develop and evaluate new
medicines, regulate their use

Optimize the use of existing medicines, find new indications

Define the basis for variability in therapeutic and toxic
responses to medicines

What is the measurement to see whether some toxicities can
be managed and may be acceptable? -- CORRECT ANSWER--
>risk/benefit ratio

What is the characteristic of Risk/Benefit ratio? -- CORRECT
ANSWER-->It is contextual, which tells you it is depending on
the drug and disease that we intend to treat

For example, it is not the same to consider potentially serious
toxicity for a drug intended to treat HYT, which is a medical
condition that needs lifelong therapy, compared to treatment
of cancer, a disease that is potentially lethal over the short
2
Page

, term, and that requires very intense treatment with
combination of drugs that have very significant toxicity

_____ is a condition or brings up situations, if you will, where
an underlying genetic variant may predispose individuals to
severe toxicity to drugs -- CORRECT ANSWER-->Genetics

What is the name of genetic variant and the name of antiviral
drug?

Individuals that carry _____ variant are at very high risk of
_____ hypersensitivity. This drug is used in the treatment of
HIV infections and AIDS, and prior to instituting treatment with
the drug, every pt is first tested for this variant, _____, and
alternatives must be found if the patient have the variant --
CORRECT ANSWER-->HLA-B*5701 and abacavir

What is the name drug that causes the-drug-induced liver
disease (DILI) and the name of variant associated with this DILI?
-- CORRECT ANSWER-->Flucoxacillin and HLA-B *5701

What is the name of genetic variant and the name of drug?
3
Page

, _____ may predispose to severe _____-induced, a serious
cutaneous ADR that actually can be fatal -- CORRECT ANSWER--
>HLA-B*1502 and Carbamazepine

What is the name of drug-induced disease associated with HLA-
B*1502? -- CORRECT ANSWER-->Stevens-Johnson syndrome

What is the name of disease exemplified as unacceptable drug
toxicity that induces an abnormal, life-threatening episode/ADR
of the polymorphic ventricular tachycardia that you might be
able to see in ECG record -- CORRECT ANSWER-->Torsade’s de
Pointes

What is the name of drug that was historically the first non-
sedating antihistamine under the brand name of Seldane, but
subsequently withdrawn from the market due to the risk of
drug-induced arrhythmias? -- CORRECT ANSWER-->Terfenadine

What are the words in the blanks?

_____ is carboxylic metabolite of _____ which is a non-sedating
antihistamine under the brandname of Allegra but does not
have the risk of a drug-induced arrhythmia. Recently it is also
called _____ -- CORRECT ANSWER-->Terfenadine Carboxylate,
Terfenadine, and Fexofenadine
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Examen

Introduction to Clinical Pharmacology 10th Edition by Constance Visovsky Questions And Correct Answers Verified Latest Guaranteed Pass Grade A + UPDATED!!

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