Notas de lectura
Lecture 3. T cell priming in the COVID-19 era (AM_470656)
- Grado
- Institución
- Book
T cell priming, techniques to measure T cell responses, and COVID-19 and T cells.
[Mostrar más]Vista previa 2 fuera de 13 páginas
Vista previa 2 fuera de 13 páginas
Añadir al carrito
Añadir al carrito
Libro relacionado
Título del libro:
Autor(es):
- Edición:
- ISBN:
- Edición:
Más resúmenes para
-
Lecture 9. The immune system in the brain (neuro-immunology) (AM_470656)
-
Lecture 7. Immune response to glycolipids and polysaccharides (AM_470656)
-
Lecture 6. Immune deficiencies (AM_470656)
Vendedor
Seguir
nuriafarras
Vista previa del contenido
Molecular Cell Biology and ImmunologyLecture 3. T cell priming in the Covid-19 era
INDEX
1. Essentials of T cell priming .......................................................................................................................................................................... 1
1.1. Activation of the T cells by DC ............................................................................................................................................................. 1
1.2. phases of the T cell response .............................................................................................................................................................. 2
1.3. helper T cells and B cell response ........................................................................................................................................................ 2
1.4. naïve, effector and memory T cells ..................................................................................................................................................... 3
1.4.1. Memory cells ........................................................................................................................................................................................ 3
1.5. Identification techniques .................................................................................................................................................................... 4
1.6. Exhaustion of T cellS ........................................................................................................................................................................... 4
2. MHC molecules and peptides ...................................................................................................................................................................... 5
2.1. Polymorphic ....................................................................................................................................................................................... 6
3. Techniques to measure Ag specific T cell response ...................................................................................................................................... 6
3.1. proliferation ....................................................................................................................................................................................... 6
3.2. Cytokine production ........................................................................................................................................................................... 7
3.3. Cytotoxicity ........................................................................................................................................................................................ 7
3.4. Upregulation of activation markers (AIM assay) ................................................................................................................................. 7
3.5. MHC staining ...................................................................................................................................................................................... 8
4. COVID-19 and T cell responses .................................................................................................................................................................... 8
4.1. COVID-19 in the Netherlands .............................................................................................................................................................. 8
4.2. Human coronaviruses ......................................................................................................................................................................... 8
4.3. SARS-CoV-2 virus ................................................................................................................................................................................ 8
4.4. vaccine development .......................................................................................................................................................................... 9
4.5. Introduction of the vaccine ................................................................................................................................................................. 9
4.6. Immune response against vaccination .............................................................................................................................................. 10
4.6.1. Memory response .............................................................................................................................................................................. 10
4.6.2. T cell response.................................................................................................................................................................................... 11
4.6. Unexposed individuals ...................................................................................................................................................................... 11
, COVID-19. In the end we get Ab, helper cells and cytotoxic cells. We will focus on the T cell response.
1. ESSENTIALS OF T CELL PRIMING
Naïve CD4 and CD8 T cells are activated by DCs in the secondary lymphoid organs.
• DCs are the ones that can activate naïve
cells. → The 1st activation is in the
secondary lymphoid organ by the
presentation of the DC.
o They can activate CD8
(cytotoxic with granzyme, etc.)
o CD4 helper cells help:
▪ Antibody response
▪ B cell in the germinal
center to become the
plasma cells and also
the hypermutation
and positive selection.
▪ They help CD8 T cell
priming.
• Effector cells can be activated by any cell
that presents the antigen.
1.1. ACTIVATION OF THE T CELLS BY DC
T cells are able to prime naïve B cells because they can provide the three signals: (exam)
- Antigen presented in the MHC molecule that can be recognized in the T cell receptor. Then, it decides
the T cell that responds (aprox 100.000 cells per epitope), the ones that respond need the other signals. Is
they responds it means have the receptor for the Ag.
- Co-stimulation by CD80/86 that bind to CD28 and leads to proliferation and expansion of the cell.
1
Los beneficios de comprar resúmenes en Stuvia estan en línea:
Garantiza la calidad de los comentarios
Compradores de Stuvia evaluaron más de 700.000 resúmenes. Así estas seguro que compras los mejores documentos!
Compra fácil y rápido
Puedes pagar rápidamente y en una vez con iDeal, tarjeta de crédito o con tu crédito de Stuvia. Sin tener que hacerte miembro.
Enfócate en lo más importante
Tus compañeros escriben los resúmenes. Por eso tienes la seguridad que tienes un resumen actual y confiable. Así llegas a la conclusión rapidamente!
Preguntas frecuentes
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
100% de satisfacción garantizada: ¿Cómo funciona?
Nuestra garantía de satisfacción le asegura que siempre encontrará un documento de estudio a tu medida. Tu rellenas un formulario y nuestro equipo de atención al cliente se encarga del resto.
Who am I buying this summary from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller nuriafarras. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy this summary for $3.79. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
45,681 summaries were sold in the last 30 days
Founded in 2010, the go-to place to buy summaries for 14 years now