NSG 5003 WEEK 2 QUIZ / NSG5003 WEEK 2 QUIZ: ADVANCED PATHOPHYSIOLOGY-Hypersensitivity is best defined as a(an) - c.
Altered immunologic response to an antigen that results in disease
A hypersensitivity reaction that produces an allergic response is called: - Anaphylaxis
The common hay fever ...
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NSG5003 WEEK 2 QUIZ: ADVANCED PATHOPHYSIOLOGY
Hypersensitivity is best defined as a(an) - c.
Altered immunologic response to an antigen that results in disease
A hypersensitivity reaction that produces an allergic response is called: - Anaphylaxis
The common hay fever allergy is expressed through a reaction that is mediated by
which class of immunoglobulins? - IgE
Which type of antibody is involved in type I hypersensitivity reaction? - IgE
Blood transfusion reactions are an example of: - Alloimmunity
During an IgE-mediated hypersensitivity reaction, which leukocyte is activated? - c.
Eosinophils
During an IgE-mediated hypersensitivity reaction, the degranulation of mast cells is a
result of which receptor action? - Histamine bound to H2
What characteristic do atopic individuals have that make them genetically predisposed
to develop allergies? - c.
Greater quantities of IgE
What is the mechanism that results in type II hypersensitivity reactions? - d.
Antibodies bind to the antigens on the cell surface.
When mismatched blood is administered causing an ABO incompatibility, the
erythrocytes are destroyed by - a.
Complement-mediated cell lysis
When antibodies are formed against red blood cell antigens of the Rh system, the blood
cells are destroyed by: - Phagocytosis in the spleen
When soluble antigens from infectious agents enter circulation, tissue damage is a
result of: - d.
Neutrophil granules and toxic oxygen products
How are target cells destroyed in a type II hypersensitivity reaction? - d.
Natural killer cells
,Graves disease (hyperthyroidism) is an example of which type II hypersensitivity
reaction? - Modulation
Type III hypersensitivity reactions are a result of which of the following? - b.
Antibodies binding to soluble antigens that were released into body fluids and the
immune complexes being deposited in the tissues
A type IV hypersensitivity reaction causes which result? - .
Lymphokine-producing Th1 cells directly attacking and destroying cellular targets
In a type III hypersensitivity reaction, the harmful effects after the immune complexes
that are deposited in tissues are a result of: - Complement activation
Raynaud phenomenon is classified as a type III hypersensitivity reaction and is due to:
- a.
Immune complexes that are deposited in capillary beds, blocking circulation
Deficiencies in which element can produce depression of both B- and T-cell function?
- Zinc
When the maternal immune system becomes sensitized against antigens expressed by
the fetus, what reaction occurs? - Alloimmunity
Tissue damage caused by the deposition of circulating immune complexes containing
an antibody against the host DNA is the cause of which disease? - Systemic lupus
erythematosus
Why does tissue damage occurs in acute rejection after organ transplantation? - a.
Th1 cells release cytokines that activate infiltrating macrophages, and cytotoxic T cells
directly attack the endothelial cells of the transplanted tissue.
Which blood cell carries the carbohydrate antigens for blood type? - Erythrocytes
A person with type O blood is likely to have high titers of which anti-antibodies? - A
and B
Which class of immunoglobulins forms isohemagglutinins? - IgM
Which component of the immune system is deficient in individuals with infections
caused by viruses, fungi, or yeast? - T cells
, In which primary immune deficiency is there a partial-to-complete absence of T-cell
immunity? - DiGeorge syndrome
How many months does it take for the newborn to be sufficiently protected by
antibodies produced by its own B cells? - 6 to 8
Considering the effects of nutritional deficiencies on the immune system, severe
deficits in calories and protein lead to deficiencies in the formation of which immune
cells? - T cells
Urticaria are a manifestation of a which type of hypersensitivity reaction? - Type I
Graves disease is a result of: - c.
Autoantibodies binding to thyroid-stimulating hormone (TSH)-receptor sites
Raynaud phenomenon is an example of which type of hypersensitivity? - Type III
Which statement is true concerning an atopic individual? - They tend to produce more
Fc receptors.
Which statement is true regarding immunodeficiency? - a.
Immunodeficiency is generally not present in other family members
A person with type O blood is considered to be the universal blood donor because type
O blood contains which of the following? - No antigens
Immunoglobulin E (IgE) is associated with which type of hypersensitivity reaction? -
Type I
Graves disease is an autoimmune disease that results in which maternal antibody? - b.
Affecting the receptor for TSH, causing neonatal hyperthyroidism
When a tuberculin skin test is positive, the hard center and erythema surrounding the
induration are a result of which of the following? (Select all that apply.) - T
lymphocytes and Macrophages
Exposure to which of the following could result in a type IV hypersensitivity reaction?
(Select all that apply.) - Poison Ivy, Neomycin, Nickel, Detergents
Which disorders are considered autoimmune? (Select all that apply - Crohns,
Addisons, Rheumatoid arthritis, systemic lupus erythematosus
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