GPHC BNF: Infections / Exam Questions and answers/ Signs and symptoms of infection What is antimicrobial stewardship? What are the principles of antibiotic prescribing? What antibiotics should be avoided in children? Tetracyclines in children less than 12 years old Quinolones cause arthropathy so avoid under 18 years old Which antibiotic has the highest risk of C.diff? Clindamycin What alternatives to give to patients that are penicillin allergic? Macrolides Metronidazole in dental infection What antibiotics should be avoided in penicillin -allergy? Cephalosporins Penicil lin What antibiotics should be avoided in renal impairment? Nephrotoxic drugs: Aminoglycosides Glycopeptides Avoid: - Tetracyclines apart for Minocycline/Doxycycline - Nitrofurantion (eGFR <45) What antibiotics should be avoided in hepatic impairment? Hepatotoxic drugs: Rifampicin Tetracyclines (apart from doxy/lyme) Reduce metronidazole dose if severely impaired Co-amoxiclav & Flucloxacillin can cause cholestatic jaundice What are the safest antibiotics to give in pregnancy? Penicillin Cephalosporins What antibiotics are contra -indicated and to be avoided in pregnancy? Contra -indicated Tetracyclines Trimethoprim Nitrofurantoin causes nausea - avoid at term Avoid Metronidazole Chloramphenicol Aminoglycosides Quinolones Sulphonamides What is the antibi otic cautionary and advisory label? What are the side effects of antibiotics? What antibiotics treat staphylococci? Flucloxacillin What antibiotic treats MRSA? Vancomycin What antibiotics tr eat Streptococci? Benzylpenicillin or Phenoxymethylpenicillin What antibiotic treats anaerobic bacteria? Metronidazole What antibiotic treats Pseudomonas aeruginosa? Gentamicin What is the side effect of clindamycin? C.diff What is the side effect of linezolid? Blood disorders e.g. leucopenia and thrombocytopenia Report bone marrow suppression Optic neuropathy if more than 28 days use Report visual symptoms
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