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Comsae Practice Passed!! CD4 AND CD8 T LYMPHOCYTES ARE NORMALLY FOUND IN - ANS>thymic medulla? Hypersensitivity: - ANS>4 types anaphylactic and atopic (type I); cytotoxic (ab mediated type II); Immune complex (type III) Delayed (cell mediated, type IV) ACID!!! TYPE I HSR I=IgE - ANS>Anaphylactic and atopic --free ag cross link IgE!!! on presensitized mast cells and basophils>> vasoactive amines that act at post capillary venues (like histamine); rapid develop after antigen exposure bc of preformed antibody; delayed phase results from mast cells and basophils releasing cytokines that induce cellular inflamm Type I = first and fast - ANS>Type I II and III are all antibody mediated Test: skin test or blood test (ELISA) for allergen specific IgE; Ex: anaphylaxis (food, drug, or bee sting) Interpretation of Type I - ANS>Allergen binds specific allergen IgE's on Mast cells and basophis>>leading to degranulation "" (vasoactive amines that act @ post cap venules) Type II HSR - ANS>Antibodies bind to cell -surface Ags>> cell destruction, inflammation, and cellular dysfunction Cell destruction - ANS>cell is opsonized (coated) by Abs, leading to either: 1. phagocytosis and/or activation of complement system 2. NK cell killing (ab dependent cellular cytotoxicity) **complement or cytotoxicity!!** Inflammation --bind of abs to cell surfaces>>active of complement system and Fc receptormediated inflammation; Cell dysfunction: abs bind to cell surface receptors> abnormal blockade or active of downstream process Direct Coombs Test - ANS>For type II HSR direct Coombs detects abs attached directly to the RBC surfaceLos beneficios de comprar resúmenes en Stuvia estan en línea:
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