A WT1 mutation of Cr11 describes what urinary disorder?
~ Wilm's tumor
3 y/o patient with mother presents to the office. Mother voices concerns over a large
abdominal mass. Mother notes that he was born with congenital GU abnormalities
and without an iris. You notice that one side of this pa...
NUR 612 EXAM 5
Questions and Answers
How much % CO do the kidneys recieve?
✓~ 20-25%
"filters essential substances and reabsorbs substances needed to maintain normal
composition" describes what organ?
✓~ the KIDNEY!
SATA: Which of the following mechanisms controls RBF?
a. intrinsic
b. autoregulation
c. extrinsic
d. protein & glucose
e. sympathetic controls
✓~ a, c, d
Intrinsic, extrinsic and protein and glucose
,Of the intrinsic regulation of RBF, the juxtaglomerular complex contains _________
necessary to convert angiotensinogen to angiotensin I
✓~ Renin
What RBF intrinsic regulation mechanism has this function:
"plays essential feedback role in linking ABP and RBF to GFR"
✓~ Juxtaglomerular complex
How does a sympathetic NS stimulating event like shock or trauma affect RBF?
✓~ Afferent and Efferent arteriole constriction --> decreased RBF, GFR --> decreased
UOP
What affect do blood borne hormones angiotensin II, ADH, endothelins have on
RBF?
✓~ vasoCONSTRICTION
What affect do blood borne hormones dopamine, nitric oxide, prostaglandinds have
on RBF?
✓~ vasoDILATION
[T/F]: NSAIDS INCREASE RBF
,✓~ False!
NSAIDS inhibit prostaglandin synthesis --> decreased RBF and GFR
How does a decreased GFR affect Na + Cl?
✓~ increased Na + Cl reabsorption --> decreased Na + Cl to the macula densa
What are the results of decreased Na + Cl to the macula densa?
✓~ 1. decreased resistance in afferent arterioles --> increased GFR
2. increased renin release from JG cells
Describe how protein and glucose affects RBF
✓~ amino acids and Na absorbed together --> decreased Na to macula densa --> JG cell
activation --> increased RBF
Where are the glomeruli and convoluted tubules located?
✓~ in the cortex
Renal pyramids, loop of henle, renal pelvis and collecting system are located
________
✓~ in the medulla
, Afferent arteriole is supplied by ________
✓~ interlobar ARTERY
Efferent arteriole is supplied by ________
✓~ interlobar VEIN
Where are most nephrons located?
✓~ 85% are cortical
(short distance)
The juxtamedullary nephrons are the primary site of __________
__________________
✓~ urine concentration
[T/F]: the glomerulus is a low pressure capillary filtration system
✓~ FALSE - it is HIGH pressure
due to the hydrostatic pressure
_________ is protein free plasma
✓~ Filtrate
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