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PHCY 631: Headaches Questions with Correct Answers
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PHCY 631: Headaches Questions with CorrectAnswers
Although the patho of a migraine headache isn't clear, what is thought to
associate with how migraines occur? Correct Answer-- cortical
spreading depression (causes some pain and is what's associated with
aura; can effect BBB permeability)
- trigeminovascular system (can cause a cascade of neuropeptides that
can lead to vasodilation and neurogenic inflammation)
- sensitization (decreases pain threshold, which leads to a magnified
response)
- serotonin (activation is important in treatment)
- calcitonin gene-related peptide/ CGRP (vasodilator; newer drugs are
targeting this to initiate vasoconstriction for treatment)
How do you diagnose migraine w/ aura? Correct Answer-- at least 5
attacks
- attacks last 4-72 hours (untreated or unsuccessfully treated)
- attacks have at least 2 of the following: unilateral location, pulsating
quality, moderate/severe intensity, aggrevated by or avoidance of routine
physical activity
- during headache at least one of the following occurs: N/V or both,
phosophobia and/or phonophobia, not attributed to another disorder
How do you diagnose migraine w/ aura? Correct Answer-- at least 2
attacks
, - migraine aura fulfills criteria for typical aura, hemiplegia migraine,
retinal migraine, or brainstem aura
- not attributed to another disorder
What is a typical aura? Correct Answer-- fully reversible visual, sensory,
or speech symptoms (or any combination) but no motor weakness
- homonymous or bilateral visual symptoms including positive features
(flickering lights, spots, lines) or negative features (loss of vision) or
unilateral sensory symptoms including positive features (pins/needles) or
negative features (numbness), or any combination
- At least 2 of the following: at least one symptom that develops
gradually over a min of 5 min or different symptoms that occur in
succession or both, each symptom lasts 5-60 minutes, headache that
meets criteria for migraine w/o aura begins during the aura or follows
aura within 60 min.
When are migraine headaches typically diagnosed? Correct Answer-in
2nd/3rd decade of life
What can lead to medication-overuse headaches? Correct Answer->15
days: NSAIDs/monotherapy with analgesics
>10 days: triptans
>9 days: combo analgesics
>3 days: butalbital products
Who is eligible for PPX treatment? Correct Answer-- recurring
migraines that produce significant disability despite acute therapy
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