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PCB 3233 EXAM 2 questions with complete solutions
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PCB 3233 EXAM 2 questions with complete solutions
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PCB 3233 EXAM 2Induced innate immune response - correct answer ✔✔-Inflammation
-Leukocytes called into the site of infection
-Soluble molecules made and secreted into the blood and brought to the site of the infection
Leukocytes in the order to action - correct answer ✔✔1. Neutrophils - Mass quantities
2. Monocytes
3.Lymphocytes - days later
2 cell type recognition - correct answer ✔✔1. NK - looking at your own cells
2. Macrophages - looking at pathogen directly
Macrophages - correct answer ✔✔use toll like receptors and phagocytic receptors
PAMP - correct answer ✔✔pathogen associated molecular patterns - on pathogen
PRR - correct answer ✔✔pattern recognition receptors - on leukocyte
Are there different receptor used for phagocytosis vs. cytokine creation and secretion(signalling)? -
correct answer ✔✔yes
What are the 5 cytokines? - correct answer ✔✔IL-1
TNF-a
IL-6
CXCL8
IL-12
,Which cytokines are pyrogens? - correct answer ✔✔IL-1
TNF-a
IL-6
What do heat cytokines (Pyrogens) lead to? - correct answer ✔✔Lead to fever
Which cytokines activate endothelial cells? - correct answer ✔✔IL-1 and TNF-a
What does the activation of endothelial cells lead to? - correct answer ✔✔Vasodilation and Vascular
premeability
NK cells provides an early response for which kind of infection? - correct answer ✔✔Viral Infection
NK recognizes two types of receptors - correct answer ✔✔Activating receptors and inhibitory receptors
Activating receptors recognize - correct answer ✔✔(Stress induced) activating ligands which leads to
apoptosis.
Inhibitory receptors recognizes - correct answer ✔✔MHC 1 on all nucleated cells.
1st effector cell - correct answer ✔✔Resident Macrophages which is prevalent in connective tissues
CR1 (complement receptor 1) binds to? - correct answer ✔✔C3b
C3b is degraded by what to become iC3b? - correct answer ✔✔Factor I
NK cells can detect? - correct answer ✔✔MHC molecules
Which receptor can recognize both Gram(-) and Gram(+)? - correct answer ✔✔Scavenger Receptor A
(SR-A)
, Which leukocyte would be first out to the sight of infection in mass quantities? - correct answer
✔✔Neutrophils
Macrophages Receptors (PRR): - correct answer ✔✔Mannose Receptor
CR-3
CR-4
Dectin-1
SR-A (Scavenger Receptor-A)
SR-B (Scavenger Receptor - B)
LPS (also known as CD14)
TLR
MARCO
Can all nucleated cells use MHC 1? - correct answer ✔✔yes
Macrophages are longlived compared to what? - correct answer ✔✔Neutrophils
What can CR1 do for you? - correct answer ✔✔Bind to C3b and phagocytose what ever C3b is bound to
What are the 4 TLRs(Toll-Like Receptors)? - correct answer ✔✔TLR-3
TLR-7
TLR-5
TLR-4
What are the internal TLRs? - correct answer ✔✔TLR-3:Double stranded Viral RNA
TLR-7: Single stranded Viral RNA
What does CR-3 and CR-4 recognize? - correct answer ✔✔iC3b and LPS
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