PCB 3233 Exam 6 Study Guide Chapter
11
If you got multiple immunizations with the same antigen, what would you find with regard to Ab levels
IgG and antibody affinity? - correct answer ✔✔More IgG in body and higher antibody affinity to specific
antigen.
What is the difference between protective immunity and secondary immune response? What
cells/molecules are used in each? - correct answer ✔✔Protective Immunity = Protection provided by the
Ab's created in the primary immune response.
Do naive B-cells help in a secondary immune response? What about primary immune response? -
correct answer ✔✔Naive B-cells do NOT participate in the secondary IR! They DON'T HELP.
BUT!! They do help in the primary immune response because they will have the inhibitory receptor
(FC(y)RIIB1) on surface. (FC(y)RIIB1) prevents naive B-cells from being activated in secondary IR and leads
to naive B-cells death by apoptosis. This means that only high affinity, isotype switched antibodies will be
produced to rid pathogen.
ALSO!! In the primary response naive B-cells binds the pathogen and activated and becomes an
antibody-producing plasma cell. This will allow production of low affinity IgM antibodies.
Do B-cells go through the same types of processes during a secondary immune response as they do
during a primary immune response? - correct answer ✔✔YES.
Memory B-cells recirculate the same same as naive B-cells and are activated in the secondary typhoid
tissue by CD4 T-cells.
Do we typically have more memory B-cells specific for antigen in a secondary IR than we had naive B-cell
(Ag specific) in the primary response? - correct answer ✔✔There are many more memory B cells at the
start of the secondary IR than there were naive B-cells at the beginning of the primary IR.
Know what original antigenic sin is and how to use the concept if you are asked a clinical type of
question. Can naive B-cell be activated in a secondary immune reponse? can we use this knowledge to
help us in things like hemolytic disease of the newborn? (How does RhoGAM work)? How does the
original antigenic sin work with infections such as influenza? - correct answer ✔✔No. Naive B-cells are
11
If you got multiple immunizations with the same antigen, what would you find with regard to Ab levels
IgG and antibody affinity? - correct answer ✔✔More IgG in body and higher antibody affinity to specific
antigen.
What is the difference between protective immunity and secondary immune response? What
cells/molecules are used in each? - correct answer ✔✔Protective Immunity = Protection provided by the
Ab's created in the primary immune response.
Do naive B-cells help in a secondary immune response? What about primary immune response? -
correct answer ✔✔Naive B-cells do NOT participate in the secondary IR! They DON'T HELP.
BUT!! They do help in the primary immune response because they will have the inhibitory receptor
(FC(y)RIIB1) on surface. (FC(y)RIIB1) prevents naive B-cells from being activated in secondary IR and leads
to naive B-cells death by apoptosis. This means that only high affinity, isotype switched antibodies will be
produced to rid pathogen.
ALSO!! In the primary response naive B-cells binds the pathogen and activated and becomes an
antibody-producing plasma cell. This will allow production of low affinity IgM antibodies.
Do B-cells go through the same types of processes during a secondary immune response as they do
during a primary immune response? - correct answer ✔✔YES.
Memory B-cells recirculate the same same as naive B-cells and are activated in the secondary typhoid
tissue by CD4 T-cells.
Do we typically have more memory B-cells specific for antigen in a secondary IR than we had naive B-cell
(Ag specific) in the primary response? - correct answer ✔✔There are many more memory B cells at the
start of the secondary IR than there were naive B-cells at the beginning of the primary IR.
Know what original antigenic sin is and how to use the concept if you are asked a clinical type of
question. Can naive B-cell be activated in a secondary immune reponse? can we use this knowledge to
help us in things like hemolytic disease of the newborn? (How does RhoGAM work)? How does the
original antigenic sin work with infections such as influenza? - correct answer ✔✔No. Naive B-cells are
