NAPLEX - Chronic Kidney Disease McGraw
Hill. Exam Questions And Answers |Latest
2025 | Guaranteed Pass.
To understand the mechanism of action for medications used for the treatment of mineral and
bone disorders that are common in patients with chronic kidney disease (CKD-MBD), a
foundational knowledge of the pathophysiology of this disorder is necessary. Identify the
correct sequence of pathophysiological events that can result in this complication.
A
Alterations in calcium and phosphorous concentrations in the kidney and bone
B
Increase parathyroid hormone production
C
Reduction in intestinal absorption of calcium
D
Reduction in plasma levels of vitamin D - Answer✔
A 44-year-old man with end-stage renal disease (receives hemodialysis on Monday-Wednesday-
Friday), diabetes, hypertension, and peripheral neuropathy presents to the pharmacist for
optimization of medication therapy. Since the start of hemodialysis a month prior, the patient
states that he has difficulty remembering to take his medications with meals and he has
experienced two episodes of hypoglycemia. He denies medication or food allergies and does
not recall his recent immunizations.
Ht 5'11" Wt 90 kg
Vitals: BP 160/89 (baseline BP prior to hemodialysis 145/80) HR 72 RR 18 Temp 98.6
1
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Pertinent labs:
Hgb 9.2
Hct 30
TSAT 18
Serum ferritin 69
Retic count 1.01
Albumin 2.9
PO4 7.5
Ca 7.8
iPTH 420
Hgb A1c 10.5
Current medications:
ECaspirin 81 mg PO daily
Insulin glargine 30 units subcutaneous (SubQ) QHS
Insulin lispro 10 units SubQ three times daily with meals
Metoprolol 25 mg PO BID
Losartan 50 mg PO daily
Iron sucros - Answer✔all
Common side effects associated with all parenteral iron products (dextran or non-dextran
containing) include hypotension, peripheral edema, headache, nausea, and muscle cramps.
Although rare (<1%), anaphylactic/anaphylactoid reactions including serious or life-threatening
responses have been reported. Cardiopulmonary resuscitation equipment and emergency
personnel should be available during initial administration until tolerance has been
demonstrated.
INFed is the brand name of iron dextran.
Venofer is the brand name of iron sucrose.
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Sodium ferric gluconate's corresponding brand name is Ferrlecit.
Ferric carboxymaltose's corresponding brand name is Injectafer.
A 44-year-old man with end-stage renal disease (receives hemodialysis on Monday-Wednesday-
Friday), diabetes, hypertension, and peripheral neuropathy presents to the pharmacist for
optimization of medication therapy. Since the start of hemodialysis a month prior, the patient
states that he has difficulty remembering to take his medications with meals and he has
experienced two episodes of hypoglycemia. He denies medication or food allergies and does
not recall his recent immunizations.
Ht 5'11" Wt 90 kg
Vitals: BP 160/89 (baseline BP prior to hemodialysis 145/80) HR 72 RR 18 Temp 98.6
Pertinent labs:
Hgb 9.2
Hct 30
TSAT 18
Serum ferritin 69
Retic count 1.01
Albumin 2.9
PO4 7.5
Ca 7.8
iPTH 420
Hgb A1c 10.5
Current medications:
ECaspirin 81 mg PO daily
Insulin glargine 30 units subcutaneous (SubQ) QHS
Insulin lispro 10 units SubQ three times daily with meals
3