NUR 325 Exam 3. Drugs
ACE Inhibitor - answer- captopril (Capote)
- enalapril (Vasotec)
- eosinophil (Monoprix)
- lisinopril (Prinivil)
Captopril Therapeutic Uses - answer- HTN
- HF
- diabetic nephropathy
- left ventricular dysfunction following MI (ramipril)
Captopril Adverse Drug Reactions - answer- severe hypotension after 1st dose
- dry, nonproductive cough
- rash + metallic taste
- angioedema
- hyperkalemia
- neutropenia
Captopril Administration - answer- PO BID/TID
- 2-3x daily for HTN
- 3x daily for HF
- give 1 hr ac
Captopril Contraindications - answer- teratogenic
- angioedema/allergy
- hypotension
- liver disease w/ elevated liver enzymes
Captopril Precautions - answer- decreased renal fxn
- bone marrow depression/ immunosuppresion
- rheumatoid arthritis
- cardiovascular disease
- cerebral vascular disease
- heart failure
- hyperkalemia
- hyponatremia
- older adults
- less effective in African Americans
Captopril Interactions - answer- potassium-sparing diruetics
- potassium supplements
- salt substitutes
, - antihypertensive drugs, diuretics, nitrates (increase risk of hypotension)
- NSAIDs decrease effect
- Food decreases absorption
- may cause lithium toxicity
ARBs meaning - answerangiotensin II receptor blockers
What ARB prevents cerebral vascular accidents (stroke)? - answerlosartan
What ARBs help manage diabetic nephropathy? - answerlosartan + irbesartan (Avapro)
What ARBs help treat heart failure? - answer- valsartan (Diovan)
- candesartan (Atacand) (also prevents migraines)
Losartan brand name - answerCozaar
Losartan Therapeutic Use - answer- HTN
- Prevents stroke
- Manages diabetic nephropathy
Losartan Adverse Drug Reactions - answer- angioedema (less than ACE inhibitors)
- headache
- dizziness
- hypotension
- insomnia
Losartan Administration - answer- PO only
- may be combined w/ thiazine diuretic, Hyzaar
- w/ or w/o food
- 1st dose lowered for pts on diuretics or w/ liver failure
Losartan Contraindications - answer- teratogenic
- allergy
- kids <6
- kids >6 w/ low creatinine clearance
Losartan Precautions - answer- concurrent diuretic use
- hyperkalemia
- liver/renal disorders
- pregnancy
Losartan Interactions - answer- antihypertensives increase risk of hypotension
- NSAIDs decrease effect and increase risk of renal complications
Aldosterone Antagonist - answer- eplerenone (Inspra)
ACE Inhibitor - answer- captopril (Capote)
- enalapril (Vasotec)
- eosinophil (Monoprix)
- lisinopril (Prinivil)
Captopril Therapeutic Uses - answer- HTN
- HF
- diabetic nephropathy
- left ventricular dysfunction following MI (ramipril)
Captopril Adverse Drug Reactions - answer- severe hypotension after 1st dose
- dry, nonproductive cough
- rash + metallic taste
- angioedema
- hyperkalemia
- neutropenia
Captopril Administration - answer- PO BID/TID
- 2-3x daily for HTN
- 3x daily for HF
- give 1 hr ac
Captopril Contraindications - answer- teratogenic
- angioedema/allergy
- hypotension
- liver disease w/ elevated liver enzymes
Captopril Precautions - answer- decreased renal fxn
- bone marrow depression/ immunosuppresion
- rheumatoid arthritis
- cardiovascular disease
- cerebral vascular disease
- heart failure
- hyperkalemia
- hyponatremia
- older adults
- less effective in African Americans
Captopril Interactions - answer- potassium-sparing diruetics
- potassium supplements
- salt substitutes
, - antihypertensive drugs, diuretics, nitrates (increase risk of hypotension)
- NSAIDs decrease effect
- Food decreases absorption
- may cause lithium toxicity
ARBs meaning - answerangiotensin II receptor blockers
What ARB prevents cerebral vascular accidents (stroke)? - answerlosartan
What ARBs help manage diabetic nephropathy? - answerlosartan + irbesartan (Avapro)
What ARBs help treat heart failure? - answer- valsartan (Diovan)
- candesartan (Atacand) (also prevents migraines)
Losartan brand name - answerCozaar
Losartan Therapeutic Use - answer- HTN
- Prevents stroke
- Manages diabetic nephropathy
Losartan Adverse Drug Reactions - answer- angioedema (less than ACE inhibitors)
- headache
- dizziness
- hypotension
- insomnia
Losartan Administration - answer- PO only
- may be combined w/ thiazine diuretic, Hyzaar
- w/ or w/o food
- 1st dose lowered for pts on diuretics or w/ liver failure
Losartan Contraindications - answer- teratogenic
- allergy
- kids <6
- kids >6 w/ low creatinine clearance
Losartan Precautions - answer- concurrent diuretic use
- hyperkalemia
- liver/renal disorders
- pregnancy
Losartan Interactions - answer- antihypertensives increase risk of hypotension
- NSAIDs decrease effect and increase risk of renal complications
Aldosterone Antagonist - answer- eplerenone (Inspra)
