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ABIM Auto-Antibodies Exam 21 Questions with Verified Answer ANA - CORRECT ANSWER SLE -- >95% sensitivity (also in SSc, Sjogren, MCTD) Anti-dsDNA - CORRECT ANSWER SLE -- >95% specificity, correlates with disease activity Anti-Smith - CORRECT ANSWER SLE -- most specific, 99%. But only 30% sensitive Anti-U1 RNP - CORRECT ANSWER MCTD (also in SLE) -- does not correlate with disease activity Anti-Ro (SSA) & Anti-La (SSB) - CORRECT ANSWER Sjogren syndrome (also in SLE)-- assoc wit...