CHEM 1005 Midterm Questions With Complete Solutions
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CHEM 1005
Établissement
University Of New England (UNE
)
Changes in the physiological variables listed below can alter the affinity of hemoglobin for oxygen. Which of the following will lower the affinity of hemoglobin for oxygen? correct answer: Increase in 2,3 bisphosphoglycerate (BPG)
A decreased affinity will increase the rate of oxygen delivery ...
chem 1005 midterm questions with complete solution
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University of New England (UNE
)
CHEM 1005
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CHEM 1005 Midterm Questions With
Complete Solutions
Changes in the physiological variables listed below can alter the
affinity of hemoglobin for oxygen. Which of the following will
lower the affinity of hemoglobin for oxygen? correct answer:
Increase in 2,3 bisphosphoglycerate (BPG)
A decreased affinity will increase the rate of oxygen delivery to
the tissues. This will occur when pH is low, there is an increase
in CO2, protons or 2,3 BPG. The other scenarios (a, c, d) will all
increase the affinity for O2.
Which of the following proteins is likely to have quaternary
structure? correct answer: A multimeric protein that contains
multiple peptide chains
Primary structure is the largely unfolded strand of amino acids,
while β- sheets and α-helices are examples of secondary
structures. How these structures interact would be an example of
tertiary structure. Quaternary structure is a characteristic of
interactions between several individual polypeptide chains.
Chymotrypsin is a protease that cleaves peptide bonds. It is
characterized as which of the following classes of enzymes?
correct answer: Hydrolases
Review the 6 classes of enzymes. Peptide bonds are cleaved and
water is released in the reaction.
,How do most enzymes reduce the activation energy needed to
move a reaction forward? correct answer: Providing an active
site most complementary the transition state
In the induced fit model, the active site is more homologous to
the transition state of the reaction and this reduces the activation
energy of the transition.
An enzyme has a mutation within the substrate binding site that
reduces the binding of the coenzyme needed for covalent
catalysis. Which of the following is likely to result as a
consequence of this mutation? correct answer: The enzyme will
not be able to form the transition state complex
Loss of coenzyme binding will result in inability to form the
transition substrate enzyme complex.
α-helices and β-sheets are primarily stabilized by which of the
following interactions? correct answer: Hydrogen bonding
All secondary structures are stabilized through hydrogen
bonding. The other forces participate in stabilizing tertiary and
quaternary structures.
Movement of ammonia from an amino acid to an α-keto acid
involves a family of enzymes best categorized as which of the
following? correct answer: Transferases
Amino transferases are commonly used in the movement of
ammonia and use the covalent catalysis "ping-pong method".
, An α-helical arrangement of amino acids is considered to be
what level of protein structure? correct answer: Secondary
structure of the protein
β- sheets and α-helices are examples of secondary structures.
How these structures interact would be an example of tertiary
structure.
A 28-year-old male is recently diagnosed with HIV. As part of
his treatment he is prescribed Nevirapine which interferes with
retroviral reverse transcriptase enzyme. Using the graph below,
which of the following best describes the impact of this drug on
its target? correct answer: It reduces the catalytic activity of the
enzyme.
There is no change in Km with the addition of the drug (as
illustrated by the lines originating on X axis at the same point).
There is a change in Vmax as illustrated by the divergence of the
lines as they cross the X axis. This could be indicative of a
noncompetitive inhibitor.
The following represents a series of reactions. As levels of B
increase, this will decrease the conversion of S3 to B. Which of
the following best describes this type of regulation in a
biosynthetic pathway? correct answer: Feedback inhibition
Feedback inhibition in biosynthetic pathways can be simple or
complex. The above example is a simple illustration of feedback
inhibition. When levels of B increase this will negatively impact
the production of B allowing substrate (S2) to be diverted A.
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