Week 3 Quiz
1. Volume neurotransmission refers to?
2. Retrograde neurotransmissions refers to?
3. Use the following CYP450 table to hypothesize drug interactions and their clinical significance for a patient on clozapine who carbamazepine, a mood stabilizer?.
4. In ligand-gated ion channel...
1. Volume neurotransmission refers to?
The diffusion of neurotransmitter to nearby neurons.
2. Retrograde neurotransmissions refers to?
The flow of neurotransmitter from postsynaptic neuron to presynaptic neuron
3. Use the following CYP450 table to hypothesize drug interactions and their
clinical significance for a patient on clozapine who carbamazepine, a mood
stabilizer? Clozapine levels would decrease, placing the patient at risk for re-
emergence of psychotic symptoms.
4. In ligand-gated ion channels, an?
Antagonist, in the presence of an agonist, can return a channel to resting state.
5. Which of the following statements about drug absorption is
trued? Concurrent use of some medications can slow absorption.
6. A neurotransmitter binds to a receptor, causing electrical impulses to travel the
neuron’s axon; it eventually releases the neurotransmitter and repeats the process with
a postsynaptic neuron. Which type of neurotransmission does this describe?
Classic synaptic neurotransmission
7. Which of the following statements is true about drug distribution?
Protein binding of psychotropic drugs can impact their availability at receptor sites.
8. Which of the following statements is true about neuronal gene
expression? Environmental factors can alter a neuron’s gene expression.
9. First pass effect refers to the?
Metabolism of the drug in the liver, prior to reaching systemic circulation
10. Matching the following.
Pharmacodynamics- Action of drugs on the body
Pharmacokinetics- Action of the body on the
drugs
Axon- The fiber-like part of the neuron that sends information to receiving neurons
Ionic filter- Regulates the flow of ions in ligand-gated channels
Excitation-secretion coupling- The conversion of an electrical signal to a chemical
signal Dendrite- The point of contact for receiving information from neurons in the
classical neurotransmission
11. Use the following CYP450 table to hypothesize drug interactions and their clinical
significance for a patient on haloperidol, a conventional antipsychotic, who is
prescribed paroxetine, an antidepressant?
Haloperidol levels would increase, placing the patient at risk for antipsychotic side
effects.
12. Elimination of a drug can be impacted by all of the following scenarios
except? A Mediterranean diet.
13. Which of the following statements is true about ligand-gated ion channels?
Allosteric modulators can enhance or inhibit ion channels when in the presence
of neurotransmitter.
14. Pharmacokinetics involves consideration all of the following except the?
, Receptor binding site of the drug
15. The direct role of transcription factors is
to? Influence gene expression
16. Second messengers are?
Intracellular messengers activated by extracellular messengers.
17. Which of the following statements about pharmacokinetics is true?
Accumulation of psychotropic drugs occurs faster in the brain then adipose tissue.
18. G-linked proteins?
Bind enzymes that synthesize second messengers.
19. Carbamazepine has a half-life of approximately 12 hours. The clinical implications of
this are?
Therapeutic blood monitoring of carbamazepine should not occur before 2 ½ days of
starting the medication.
20. When an inverse agonist binds to a G-protein linked receptor, signal transduction is?
Inactivated.
21. When an antagonist binds to a G-protein-linked receptor, signal transduction is?
Unchanged.
22. Which of the following statements is true about concentration-time curve of
medication absorption?
Steady-state refers to the point at which blood level fluctuations are mild and not
clinically significant.
23. When an agonist binds to a G-protein-linked receptor, signal transduction is?
Fully enhanced.
24. The two main targets of signal transduction cascades
are? Gene expression and phosphoproteins.
25. Which of the following methods of drug delivery is slowest to reach the bloodstreams?
Oral pills.
26. When a partial agonist binds to a G-protein-linked receptor, signal transduction is?
Partially enhanced.
27. When comparing phase I and phase II metabolism which of the following statements
is true?
Phase I metabolism refers to CYP450 enzyme activity whereas Phase II metabolism refers
to conjugation of drug.
28. Enzyme inhibition as a target of drug therapies is?
A means of preventing the degradation of neurotransmitters.
Week 4 Quiz
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