NR 546 Antidepressant and Mood Stabilizer Medication Table (Verified)

NR 546 Antidepressant and Mood Stabilizer Medication Table (Verified). Escitalopram (Lexapro) Indication  MDD 12+  GAD  Panic d/o  OCD  PTSD  Social anxiety d/o  PMDD Neurotransmitter  Serotonin Half-life 27-32 hours CYP450 Substrate for CYP450 and 3A4 No significant actions on CYP450 enzymes  Sexual dysfunction ED, delayed ejaculation, decreased sexual desire, anorgasmia  Decreased appetite, n/d, constipation, dry mouth  Insomnia and sedation, agitation, tremors, headache, dizzy  Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs  Sweating  Rare hyponatremia  Syndrome of inappropriate antidiuretic hormone Target symptoms  Depressed mood  Anxiety  Panic attacks, avoidant behavior, reexperiencing, hyperarousal  Sleep disturbance, insomnia and hypersomnia secretion  Rare seizures, induction of mania, activation of suicidal ideation Fluoxetine (Prozac) Indication  MDD 8+  OCD 7+  PMDD  Bulimia nervosa  Panic d/o  bipolar depression used with olanzapine  treatment resistant depression used with olanzapine  social anxiety d/o  PTSD Neurotransmitter  Serotonin  NE  DA Target symptoms  Depressed mood  Energy, motivation, and interest  Anxiety (can increase anxiety Half-life  Active metabolite 2 week  Parent drug 2-3 d. CYP450  Inhibits CYP450 2D6  Inhibits CYP450 3A4  Sexual dysfunction ED, delayed ejaculation, decreased sexual desire, anorgasmia  Decreased appetite, n/d, constipation, dry mouth  Insomnia and sedation, agitation, tremors, headache, dizzy  Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs  Sweating  Bruising and rare bleeding  Syndrome of inappropriate antidiuretic hormone secretion  Rare seizures, induction of mania, activation of suicidal ideation short-term)  Insomnia and hypersomnia – short-term can cause insomnia Fluvoxamine (Luvox) Indications  OCD  Social anxiety d/o  Depression  Panic d/o  GAD  PTSD Neurotransmitter  Serotonin Target symptoms  Depressed mood  anxiety Half-life  Parent drug 2-28 hours CYP450  Inhibits CYP450 1. 3A4 2. 1A2 3. 2C9/ 2C19  Sexual dysfunction ED, delayed ejaculation, decreased sexual desire, anorgasmia  Decreased appetite, n/d, constipation, dry mouth  Insomnia and sedation, agitation, tremors, headache, dizzy  Pt with bipolar or psychotic d/o may be more vulnerable to CNS-activating actions of SSRIs  Sweating  Bruising and rare bleeding  Rare hyponatremia