(Marks' Medical Biochemistry Chapter 5)
A patient was diagnosed with one of the types of sphingolipidoses, which are
congenital diseases involving the ability to degrade sphingolipids. All
sphingolipids have in common which one of the following?
A. a glycerol backbone
B. ceramide
C. phosphorylcholine
D. N-acetylneuraminic acid (NANA) Answer - B
(Marks' Medical Biochemistry Chapter 6)
Protein kinases phosphorylate proteins only at certain hydroxyl groups on
amino acid side chains. Which of the following groups of amino acids all
contain side-chain hydroxyl groups?
A. aspartate, glutamate, serine
B. serine, threonine, tyrosine
C. lysine, arginine, proline
D. alanine, asparagine, serine Answer - B
(Marks' Medical Biochemistry Chapter 13, #5)
Autopsies of patients with Alzheimer disease show protein aggregates called
neurofibrillary tangles and neuritic plaques in various regions of the brain.
These plaques exhibit the characteristic staining of amyloid. Which of the
following structural features is the most likely characteristic of at least one
protein in these plaques?
,A. a high content of beta-pleated sheet structure
B. a high content of alpha-helical structure
C. a high content of random coils
D. disulfide bond cross-links between polypeptide chains Answer - A
(Marks' Medical Biochemistry Chapter 13, #5)
The key mechanistic failure in patients with xeroderma pigmentosum involves
which of the following?
A. Mutation in the primase gene
B. Inability to excise a section of the UV-damaged DNA
C. Mutation of one of the mismatch repair components
D. Inability to synthesize DNA across the damaged region
E. Loss of proofreading capacity Answer - B
(Marks' Medical Biochemistry Chapter 30, #3)
A newborn is diagnosed with neonatal jaundice. In this patient, the bilirubin
produced lacks which of the following carbohydrates?
A. glucose
B. fructose
C. glucuronate
D. galactose
E. galactitol Answer - C
(Marks' Medical Biochemistry Chapter 31, #1)
A common intermediate in the conversion of glycerol and lactate to glucose is
which of the following?
A. pyruvate
, B. oxaloacetate
C. malate
D. glucose-6-phosphate
E. phosphoenolpyruvate Answer - D
(Marks' Medical Biochemistry Chapter 31, #2)
A patient presented with a bacterial infection that produced an endotoxin that
inhibits phosphoenolpyruvate carboxykinase (PEPCK). In this patient, then,
under these conditions, glucose production from which of the following
precursors would be inhibited?
A. alanine
B. glycerol
C. even-chain fatty acids
D. phosphoenolpyruvate
E. galactose Answer - A
(Marks' Medical Biochemistry Chapter 31, #3)
Which of the following statements best describes glucagon?
A. It acts as an anabolic hormone.
B. It acts on skeletal muscle, liver, and adipose tissue.
C. It acts primarily on the liver and adipose tissue.
D. Its concentration in the blood increases after a high-carbohydrate meal.
E. Its concentration increases in the blood when insulin levels increase. Answer
-C
(Marks' Medical Biochemistry Chapter 48, #4)
A patient presented with dysmorphia and cerebellar degeneration. Analysis of
his blood indicated elevated levels of phytanic acid and very long chain fatty
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