Traumatic brain injury – integrated
approaches to improving clinical care and
research
,Andrew I.R. Maas, MD1$; David K. Menon, MD2$; P. David Adelson, MD1;
Nada Andelic, MD4; Michael J. Bell, MD5; Antonio Belli, MD6; Peter Bragge,
PhD7 ; Alexandra Brazinova, MD8; Andras Buki, MD9; Randall M. Chesnut,
MD10; Giuseppe Citerio, MD11,12; Mark Coburn, MD13; D. Jamie Cooper, MD14;
A. Tamara Crowder, PhD15; Endre Czeiter, MD9; Marek Czosnyka, PhD16;
Ramon Diaz-Arrastia, MD17; Jens P. Dreier, MD18; Ann-Christine Duhaime,
MD19; Ari Ercole, MD2; Thomas A. van Essen, MD20,21; Valery L. Feigin, MD22;
Guoyi Gao, MD23; Joseph Giacino, PhD24; Laura E. Gonzalez-Lara, PhD25;
Russell L. Gruen, MD26; Deepak Gupta, MD27; Jed A. Hartings, PhD28; Sean Hill,
PhD29; Ji-yao Jiang23, MD; Naomi Ketharanathan MD30; Erwin J.O. Kompanje,
MD31; Linda Lanyon, PhD32; Steven Laureys, MD33; Fiona Lecky, MD34; Harvey
Levin, PhD35; Hester F. Lingsma, PhD36; Marc Maegele, MD37; Marek Majdan,
PhD8; Geoffrey Manley, MD38; Jill Marsteller, PhD39; Luciana Mascia, MD40;
Charles McFadyen, BMBCh2; Stefania Mondello, MD41; Virginia Newcombe,
MD2; Aarno Palotie, MD42,43,44; Paul M. Parizel, MD45; Wilco Peul, MD20;
Suzanne Polinder, PhD36; Louis Puybasset, MD46; Todd E. Rasmussen,
MD15,47,48; Rolf Rossaint, MD13; Peter Smielewski, PhD16; Jeannette Söderberg,
PhD32; Simon Stanworth, MD49; Murray B. Stein, MD50; Nicole von
Steinbüchel, PhD51; William Stewart, MBChB52; Ewout W. Steyerberg36,53,
PhD; Nino Stocchetti, MD54; Anneliese Synnot, MPH55,56; Braden Te Ao22, PhD;
Dick Tibboel30, MD; Alice Theadom, PhD22; Walter Videtta, MD57; Kevin K.W.
Wang, PhD58; W. Huw Williams, PhD59; Lindsay Wilson, PhD60; Kristine Yaffe,
MD61; for the InTBIR# Participants and Investigators*
$
First and second author have equally contributed to the manuscript
#
: International Traumatic Brain Injury Research (InTBIR) Initiative
*Listed at the end of the manuscript
1
Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, Arizona
© 2017. This manuscript version is made available under the Elsevier user license
http://www.elsevier.com/open-access/userlicense/1.0/
,1
Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium
2
Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
4
Division of Clinical Neuroscience, Department of Physical Medicine and Rehabilitation, Oslo University
Hospital and University of Oslo, Oslo, Norway
5
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
6
NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, UK
7
BehaviourWorks Australia, Monash Sustainable Development Institute, Monash University, Victoria, Australia
8
Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia.
9
Department of Neurosurgery, University of Pecs and MTA-PTE Clinical Neuroscience MR Research Group and
Janos Szentagothai Research Centre, University of Pecs, Hungarian Brain Research Program, Pecs, Hungary
10
Departments of Neurological Surgery, Orthopaedics and Sports Medicine University of Washington,
Harborview Medical Center, Seattle, WA, USA
11
School of Medicine and Surgery, Università Milano Bicocca, Milano, Italy
12
NeuroIntensive Care, Azienda Ospedaliera San Gerardo di Monza, Monza, Italy
13
Department of Anaesthesiology, University Hospital RWTH Aachen, Aachen, Germany
14
School of Public Health & PM, Monash University and The Alfred Hospital, Melbourne, Victoria, Australia
15
US Combat Casualty Care Research Program, Fort Detrick, MD, USA
16
Brain Physics Lab, Division of Neurosurgery, Dept of Clinical Neurosciences, University of Cambridge,
Addenbrooke’s Hospital, Cambridge, UK
17
Department of Neurology and Center for Brain Injury and Repair, University of Pennsylvania Perelman School
of Medicine, Philadelphia, USA,
18
Centrum für Schlaganfallforschung, Charité – Universitätsmedizin Berlin, Berlin, Germany
19
Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
20
Dept. of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands
21
Dept. of Neurosurgery, Medical Center Haaglanden, The Hague, The Netherlands
22
National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies,
Auckland University of Technology, Auckland, New Zealand
23
Department of Neurosurgery, Shanghai Renji hospital, Shanghai Jiaotong University/school of medicine,
Shanghai, China
24
Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation
Hospital, Charlestown, Massachusetts, USA
25
The Brain and Mind Institute, Western University, London, Ontario, Canada
26
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; and Monash University,
Australia
27
Department of Neurosurgery, Neurosciences Centre & JPN Apex trauma centre, All India Institute of Medical
Sciences, New Delhi-110029, India.
28
Department of Neurosurgery, University of Cincinnati, Cincinnati, Ohio, United States
29
Blue Brain Project, EPFL, Geneva, Switzerland CH-1202
30
Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children’s Hospital,
Rotterdam, The Netherlands
31
Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, the Netherlands
32
Karolinska Institutet, INCF International Neuroinformatics Coordinating Facility, Stockholm, Sweden
33
Cyclotron Research Center , University of Liège, Liège, Belgium
34
Centre for Urgent and Emergency Care Research (CURE), Health Services Research Section, School of Health
and Related Research (ScHARR), University of Sheffield, Sheffield ,UK
35
Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas, USA
36
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
37
Cologne-Merheim Medical Center (CMMC), Department of Traumatology, Orthopedic Surgery and
, Sportmedicine, Witten/Herdecke University, Cologne, Germany
38
Department of Neurological Surgery, University of California, San Francisco, California, USA
39
Johns Hopkins School of Medicine, Baltimore, Maryland, USA
40
Department of medical and surgical Science and Biotechnologies, Sapienza University of Rome, Rome, Italy 41
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy
42
Analytic and Translational Genetics Unit, Department of Medicine; Psychiatric & Neurodevelopmental
Genetics Unit, Department of Psychiatry; Department of Neurology, Massachusetts General Hospital, Boston,
MA, USA
43
Program in Medical and Population Genetics; The Stanley Center for Psychiatric Research, The Broad
Institute of MIT and Harvard, Cambridge, MA, USA
44
Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
45
Department of Radiology, Antwerp University Hospital and University of Antwerp, Edegem, Belgium
46
Department of Anesthesiology and Critical Care, Pitié -Salpêtrière Teaching Hospital, Assistance Publique,
Hôpitaux de Paris and University Pierre et Marie Curie, Paris, France
47
Uniformed Services University, Bethesda, MD, USA
48
Walter Reed Department of Surgery Bethesda, MD, USA
49
NHS Blood and Transplant Level 2, John Radcliffe Hospital, Oxford, UK
50
Department of Psychiatry and Department of Family Medicine and Public Health, UCSD School of Medicine,
La Jolla California, USA
51
Institute of Medical Psychology and Medical Sociology, Universitätsmedizin Göttingen, Göttingen, Germany 52
Department of Neuropathology, Queen Elizabeth University Hospital and University of Glasgow, Glasgow, UK
53
Dept of medical statistics and bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
54
Department of Pathophysiology and Transplantation, Milan University, and Neuroscience ICU, Fondazione
IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy
55
Australian & New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine,
Monash University, Australia
56
Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe
University, Melbourne, Australia
57
Hospital Nacional Professor Alejandro Posadas, Illia y Marconi El Palomar, Buenos Aires, Argentina
58
Department of Psychiatry, University of Florida, Gainesville, Florida, USA
59
Centre for Clinical Neuropsychology Research, Department of Psychology, University of Exeter, UK
60
Division of Psychology, University of Stirling, Stirling, UK
61
Divisions of Psychiatry, Neurology and Epidemiology, UCSF School of Medicine, San Francisco, California, USA
Corresponding authors:
Andrew I.R. Maas, MD
Department of Neurosurgery, Antwerp University Hospital / University of Antwerp
Wilrijkstraat 10
2650 Edegem – Belgium Phone:
+ 32 3 821 46 32
E-mail: andrew.maas@uza.be
David K. Menon, MD
Division of Anaesthesia, University of Cambridge
Box 93, Addenbrooke’s Hospital, Cambridge CB2 2QQ, UK.
Telephone +44 1223 217889; Fax: +44 1223 217887
E-mail: dkm13@wbic.cam.ac.uk
