MICR 460 Microbiology Final Exam Questions and Answers Latest (Graded)

MICR 460 Microbiology Final Exam Questions and Answers Latest (Graded) Antigen is typically found extracellularly and intracellularly within the cytosol and endosomes A 2. CD8 T cells obtain ITAM phosphorylation before CD4 T cells do during an immune response B 3. Epithelial cells first develop in bone marrow but finish their development in the thymus B 4. ELISAs measure soluble protein antigen A 5. FACS analysis can distinguish different Lin+ cell types but not Lin- cells types because Lin- cells do not express Lin+ cell surface markers B 6. Macrophages become activated by recognizing T cell dependent antigens B 7. ADCC stands for antibody dissociation and concentration of cytokines B 8. A Th17 pathogen will induce antibody generation A 9. A Th17 pathogen will induce CD40L upregulation on activating CD4 T cells in the T cell zone B 10. The equation, A-(B+C) is less than 10, is true if: B A= Number of MHC I alleles within the human species ≈150 B= The number of unique proteins within a membrane bound IgM antibody 2 C= The sum of the number of nucleotides in the RSS sequence for the rearrangement of a V (1 turn of the DNA helix) and J (2 turns of the DNA helix) DNA gene segment 12+23=35 2 Questions 11-20 are matching. Please match the BEST word or phrase from the list on the left with the BEST response on the right. Each definition on the right can be used only ONCE. Each question is worth 4 points each (40 points total). 11. Epithelial breech E2 A. B and T cell receptors 12. Immune cell effector function B1 B. Killing of infected host cell; phagocytosis 13. Innate immune system B3 C. Progenitor cells in bone marrow 14. Clonal receptors A1 D. Develops immunological memory 15. Adaptive immune system D1 E. Signal transduction; SH2 domains; cytokines 16. MHC diversity D3 A. PAMPs; MHC;peptide; protein; polysaccharides 17. Immune cell recognition A2 B. Toll-like receptors 18. Lymphocyte diversity C2 C. Combinatorial and +/- random nucleotides 19. Immune cell activation E1 D. Cytokines 20. Hybridoma E3 E. Initiates an immune response A. Due to cytosine deamination B. Required to activate the adaptive immune system C. Avidity D. Due to many different alleles within a species E. Fusing of lymphocyte with cancer cell Questions 21-36 are multiple choice. Please select the BEST response for each question. Each question is worth 5 points each (80 points total). I. Epithelial Breech: 21. Epithelial cells secrete which of the following in an attempt to fight off microbial breeches? C A. The IgM antibody as a first wave B. Granzyme B C. Antibacterial peptides D. 26S proteosome E. IL-8 22. Epithelial cells provide a barrier against infection where in the body? D A. Lungs B. Gut C. Skin D. All of the above E. A and B only 3 II. Innate Immune system: 23. The innate immune system recognizes which of the following? E A. PAMPs B. Bacterial toxin that mutates frequently at the DNA level C. DAMPs D. All of the above E. A and C 24. The innate immune system undergoes all of the following mechanisms except for which response? A A. Somatic recombination B. Recognition of PAMPs C. Recruitment of neutrophils D. Activation of T cells E. Hematopoietic development in bone marrow III. Antigen presentation to T cells by dendritic cells (DCs) 25. A maturing DC does all of the following except for which response? B A. Upregulation of co-stimulator molecules; CD80/CD86 B. Affinity maturation C. Movement to the T cell zone D. Presents self-peptide on MHCII complexes E. Presents foreign-peptide on MHCII complexes 26. Loading of peptides on MHC complexes requires which of the following? E A. Enzymes that hydrolyze phosphodiester bonds; endonucleases B. Enzymes that deaminate cytosines; AID